FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071393027> ?p ?o ?g. }

• W2071393027 abstract "During nerve growth, cytoplasmic vesicles add new membrane preferentially to the growth cone located at the distal tip of extending axons. Growth cone membrane is also retrieved locally, and asymmetric retrieval facilitates membrane remodeling during growth cone repulsion by a chemorepellent gradient. Moreover, growth inhibitory factors can stimulate bulk membrane retrieval and induce growth cone collapse. Despite these functional insights, the processes mediating local membrane remodeling during axon extension remain poorly defined.To investigate the spatial and temporal dynamics of membrane retrieval in actively extending growth cones, we have used a transient labeling and optical recording method that can resolve single vesicle events. Live-cell confocal imaging revealed rapid membrane retrieval by distinct endocytic modes based on spatial distribution in Xenopus spinal neuron growth cones. These modes include endocytic hot-spots triggered at the base of filopodia, at the lateral margins of lamellipodia, and along dorsal ridges of the growth cone. Additionally, waves of endocytosis were induced when individual filopodia detached from the substrate and fused with the growth cone dorsal surface or with other filopodia. Vesicle formation at sites of membrane remodeling by self-contact required F-actin polymerization. Moreover, bulk membrane retrieval by macroendocytosis correlated positively with the substrate-dependent rate of axon extension and required the function of Rho-family GTPases.This study provides insight into the dynamic membrane remodeling processes essential for nerve growth by identifying several distinct modes of rapid membrane retrieval in the growth cone during axon extension. We found that endocytic membrane retrieval is intensified at specific subdomains and may drive the dynamic membrane ruffling and re-absorption of filopodia and lamellipodia in actively extending growth cones. The findings offer a platform for determining the molecular mechanisms of distinct endocytic processes that may remodel the surface distribution of receptors, ion channels and other membrane-associated proteins locally to drive growth cone extension and chemotactic guidance." @default.
• W2071393027 created "2016-06-24" @default.
• W2071393027 creator A5002845006 @default.
• W2071393027 creator A5016975533 @default.
• W2071393027 creator A5022011753 @default.
• W2071393027 creator A5026261579 @default.
• W2071393027 creator A5087803592 @default.
• W2071393027 date "2012-01-30" @default.
• W2071393027 modified "2023-10-02" @default.
• W2071393027 title "Single vesicle imaging indicates distinct modes of rapid membrane retrieval during nerve growth" @default.
• W2071393027 cites W1494586189 @default.
• W2071393027 cites W1500809101 @default.
• W2071393027 cites W1526145742 @default.
• W2071393027 cites W1564176844 @default.
• W2071393027 cites W1593857113 @default.
• W2071393027 cites W1605714019 @default.
• W2071393027 cites W1652868617 @default.
• W2071393027 cites W1934142503 @default.
• W2071393027 cites W1970265615 @default.
• W2071393027 cites W1971407845 @default.
• W2071393027 cites W1972322271 @default.
• W2071393027 cites W1977314319 @default.
• W2071393027 cites W1979253073 @default.
• W2071393027 cites W1979814640 @default.
• W2071393027 cites W1981286554 @default.
• W2071393027 cites W1983034033 @default.
• W2071393027 cites W1985075710 @default.
• W2071393027 cites W1989276229 @default.
• W2071393027 cites W1991272752 @default.
• W2071393027 cites W1991735821 @default.
• W2071393027 cites W1992835639 @default.
• W2071393027 cites W1996349206 @default.
• W2071393027 cites W1998154241 @default.
• W2071393027 cites W2000853431 @default.
• W2071393027 cites W2001674490 @default.
• W2071393027 cites W2004528035 @default.
• W2071393027 cites W2008061289 @default.
• W2071393027 cites W2010402705 @default.
• W2071393027 cites W2014723616 @default.
• W2071393027 cites W2016397660 @default.
• W2071393027 cites W2021890127 @default.
• W2071393027 cites W2023213716 @default.
• W2071393027 cites W2025339136 @default.
• W2071393027 cites W2029214232 @default.
• W2071393027 cites W2032895168 @default.
• W2071393027 cites W2040577472 @default.
• W2071393027 cites W2041134111 @default.
• W2071393027 cites W2044132589 @default.
• W2071393027 cites W2051283908 @default.
• W2071393027 cites W2055804746 @default.
• W2071393027 cites W2058246130 @default.
• W2071393027 cites W2063785958 @default.
• W2071393027 cites W2064181097 @default.
• W2071393027 cites W2066165829 @default.
• W2071393027 cites W2066327803 @default.
• W2071393027 cites W2072253085 @default.
• W2071393027 cites W2072596507 @default.
• W2071393027 cites W2073368157 @default.
• W2071393027 cites W2074035736 @default.
• W2071393027 cites W2082220504 @default.
• W2071393027 cites W2082355274 @default.
• W2071393027 cites W2086441678 @default.
• W2071393027 cites W2089417835 @default.
• W2071393027 cites W2090874481 @default.
• W2071393027 cites W2093226717 @default.
• W2071393027 cites W2093844155 @default.
• W2071393027 cites W2096501276 @default.
• W2071393027 cites W2102215341 @default.
• W2071393027 cites W2102284377 @default.
• W2071393027 cites W2102459023 @default.
• W2071393027 cites W2108236053 @default.
• W2071393027 cites W2113088261 @default.
• W2071393027 cites W2117730654 @default.
• W2071393027 cites W2131384342 @default.
• W2071393027 cites W2134835707 @default.
• W2071393027 cites W2136333299 @default.
• W2071393027 cites W2142063955 @default.
• W2071393027 cites W2142286619 @default.
• W2071393027 cites W2143232130 @default.
• W2071393027 cites W2149762749 @default.
• W2071393027 cites W2151766851 @default.
• W2071393027 cites W2151888693 @default.
• W2071393027 cites W2156029588 @default.
• W2071393027 cites W2156117706 @default.
• W2071393027 cites W2160025503 @default.
• W2071393027 cites W2161591620 @default.
• W2071393027 cites W2169931542 @default.
• W2071393027 cites W4297680000 @default.
• W2071393027 cites W4300750028 @default.
• W2071393027 doi "https://doi.org/10.1186/1741-7007-10-4" @default.
• W2071393027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3337222" @default.
• W2071393027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22289422" @default.
• W2071393027 hasPublicationYear "2012" @default.
• W2071393027 type Work @default.
• W2071393027 sameAs 2071393027 @default.
• W2071393027 citedByCount "9" @default.
• W2071393027 countsByYear W20713930272012 @default.
• W2071393027 countsByYear W20713930272014 @default.
• W2071393027 countsByYear W20713930272015 @default.
• W2071393027 countsByYear W20713930272017 @default.

• next