Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071409723> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2071409723 endingPage "140" @default.
- W2071409723 startingPage "129" @default.
- W2071409723 abstract "Preliminary studies revealed that Carbopol 974P, NF resin could be incorporated into beads manufactured by extrusion and spheronization, and can slow the release of a highly water soluble drug if calcium chloride was included in the granulating fluid to reduce the tack of the wetted polymer. In this study, the same approach was used to produce high quality chlorpheniramine maleate beads with a prolonged release duration. Because of the complex nature of the extrusion and spheronization process and the various components in the bead formulations, a statistically sound factorial experiment was considered for this study. A one-half fraction of a two level factorial design with three center points was employed to estimate the effects of simultaneously modifying multiple process and formulation variables, including the Carbopol concentration, calcium chloride concentration, water content, and the spheronization speed and time. Product yield, average bead roundness, and the drug release profile were selected as responses. Increasing the Carbopol content across the experimental range resulted in a significant (P<0.05) reduction in the percentage drug released at 25, 40, and 60 min. Results suggest that combining the conditions of high Carbopol, high water, and low calcium chloride levels with low spheronization speeds at long spheronization times produce the highest quality bead with the longest drug release duration." @default.
- W2071409723 created "2016-06-24" @default.
- W2071409723 creator A5008273821 @default.
- W2071409723 creator A5022537269 @default.
- W2071409723 creator A5023150973 @default.
- W2071409723 creator A5028984349 @default.
- W2071409723 creator A5078064480 @default.
- W2071409723 creator A5078129340 @default.
- W2071409723 date "2000-04-01" @default.
- W2071409723 modified "2023-10-11" @default.
- W2071409723 title "Formulation and process considerations for beads containing Carbopol® 974P, NF resin made by extrusion-spheronization" @default.
- W2071409723 cites W1968037720 @default.
- W2071409723 cites W1978730340 @default.
- W2071409723 cites W2000836631 @default.
- W2071409723 cites W2008116134 @default.
- W2071409723 cites W2009237292 @default.
- W2071409723 cites W2029894319 @default.
- W2071409723 doi "https://doi.org/10.1016/s0378-5173(00)00372-0" @default.
- W2071409723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10802406" @default.
- W2071409723 hasPublicationYear "2000" @default.
- W2071409723 type Work @default.
- W2071409723 sameAs 2071409723 @default.
- W2071409723 citedByCount "40" @default.
- W2071409723 countsByYear W20714097232012 @default.
- W2071409723 countsByYear W20714097232013 @default.
- W2071409723 countsByYear W20714097232015 @default.
- W2071409723 countsByYear W20714097232016 @default.
- W2071409723 countsByYear W20714097232018 @default.
- W2071409723 countsByYear W20714097232019 @default.
- W2071409723 countsByYear W20714097232020 @default.
- W2071409723 countsByYear W20714097232021 @default.
- W2071409723 countsByYear W20714097232022 @default.
- W2071409723 crossrefType "journal-article" @default.
- W2071409723 hasAuthorship W2071409723A5008273821 @default.
- W2071409723 hasAuthorship W2071409723A5022537269 @default.
- W2071409723 hasAuthorship W2071409723A5023150973 @default.
- W2071409723 hasAuthorship W2071409723A5028984349 @default.
- W2071409723 hasAuthorship W2071409723A5078064480 @default.
- W2071409723 hasAuthorship W2071409723A5078129340 @default.
- W2071409723 hasConcept C105795698 @default.
- W2071409723 hasConcept C109386097 @default.
- W2071409723 hasConcept C159985019 @default.
- W2071409723 hasConcept C169222746 @default.
- W2071409723 hasConcept C185592680 @default.
- W2071409723 hasConcept C192562407 @default.
- W2071409723 hasConcept C2778958987 @default.
- W2071409723 hasConcept C2908541515 @default.
- W2071409723 hasConcept C33923547 @default.
- W2071409723 hasConcept C43617362 @default.
- W2071409723 hasConcept C77281830 @default.
- W2071409723 hasConceptScore W2071409723C105795698 @default.
- W2071409723 hasConceptScore W2071409723C109386097 @default.
- W2071409723 hasConceptScore W2071409723C159985019 @default.
- W2071409723 hasConceptScore W2071409723C169222746 @default.
- W2071409723 hasConceptScore W2071409723C185592680 @default.
- W2071409723 hasConceptScore W2071409723C192562407 @default.
- W2071409723 hasConceptScore W2071409723C2778958987 @default.
- W2071409723 hasConceptScore W2071409723C2908541515 @default.
- W2071409723 hasConceptScore W2071409723C33923547 @default.
- W2071409723 hasConceptScore W2071409723C43617362 @default.
- W2071409723 hasConceptScore W2071409723C77281830 @default.
- W2071409723 hasIssue "2" @default.
- W2071409723 hasLocation W20714097231 @default.
- W2071409723 hasLocation W20714097232 @default.
- W2071409723 hasOpenAccess W2071409723 @default.
- W2071409723 hasPrimaryLocation W20714097231 @default.
- W2071409723 hasRelatedWork W1967344847 @default.
- W2071409723 hasRelatedWork W1977803288 @default.
- W2071409723 hasRelatedWork W2071409723 @default.
- W2071409723 hasRelatedWork W2125535466 @default.
- W2071409723 hasRelatedWork W2126709062 @default.
- W2071409723 hasRelatedWork W2214207600 @default.
- W2071409723 hasRelatedWork W2354432165 @default.
- W2071409723 hasRelatedWork W2365199807 @default.
- W2071409723 hasRelatedWork W2526113930 @default.
- W2071409723 hasRelatedWork W3164516200 @default.
- W2071409723 hasVolume "199" @default.
- W2071409723 isParatext "false" @default.
- W2071409723 isRetracted "false" @default.
- W2071409723 magId "2071409723" @default.
- W2071409723 workType "article" @default.