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- W2071413019 abstract "The p19ARF p14ARF in humans protein acts as a tumour suppressor through p53 dependent and independent mechanisms. A well-established role for ARF is to regulate the post-translational modification of substrate proteins with ubiquitin and ubiquitin-like molecules such as SUMO. It is now evident that induction of ARF causes a dramatic accumulation of SUMO conjugates and this has been related to the p53 independent functions of ARF. The majority of these conjugates appear to accumulate in the nucleolus where most of ARF is also found. An obvious function for ARF, which would result in increase of SUMOylation, is to act as an atypical SUMO E3-ligase. Indeed, initial studies suggested that ARF could directly interact with the SUMO E2-conjugating enzyme Ubc9 and therefore bringing the SUMO conjugation machinery in close proximity to its interacting substrates.1 However, the highly basic charged nature of ARF makes biochemical analysis difficult and there is no clear demonstration that ARF can fulfill the criter..." @default.
- W2071413019 created "2016-06-24" @default.
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- W2071413019 date "2008-11-01" @default.
- W2071413019 modified "2023-09-25" @default.
- W2071413019 title "Targeting a nucleolar SUMO protease for degradation: A mechanism by which ARF induces SUMO conjugation" @default.
- W2071413019 doi "https://doi.org/10.4161/cc.7.21.7232" @default.
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