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- W2071414361 abstract "In the brain, retinoic acid (RA) concentrations are under tight spatio-temporal control. Here, we show that challenge of primary mouse microglia with lipopolysaccharide (LPS) results in increased release of nitric oxide (NO) and tumor necrosis factor-α (TNF-α). Co-administration of RA attenuated microglial activation. Similarly, pretreatment with RA-metabolism inhibitor liarozole potently reduced NO and TNF-α release. Conversely, activated microglia showed increased protein expression of RA-degrading cytochromes CYP26A1, CYP26B1, CYP3A4 and CYP2C. Correspondingly, RA catabolism by activated microglia was significantly increased. Our results indicate that RA reduces microglial activation, but also, conversely, that the activation state of microglia influences RA metabolism." @default.
- W2071414361 created "2016-06-24" @default.
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- W2071414361 date "2013-03-01" @default.
- W2071414361 modified "2023-10-01" @default.
- W2071414361 title "Accelerated degradation of retinoic acid by activated microglia" @default.
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- W2071414361 doi "https://doi.org/10.1016/j.jneuroim.2012.11.005" @default.
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