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- W2071421038 abstract "In this study, we compared the effects of zymosan and LPS on human monocyte-derived dendritic cells. The specific effects of zymosan on the expression of several key cytokines, including granulocyte–macrophage colony-stimulating factor (GM-CSF) and interleukins (IL-1α, IL-1β and IL-12 p70) were quite distinct from the effects of LPS. Unlike activation with LPS, DCs activated by zymosan expressed little or no IL-12 p70 due to lack of expression of the p35 subunit. However, treatment with zymosan resulted in a substantial increase in Th1 and Th17 cell-polarizing capacity of DCs. Furthermore, the GM-CSF secreted by zymosan-activated DCs enhanced IL-23 production, resulting in activation of a Th17 response. GM-CSF and IL-27, rather than IL-12 p70, were both major direct contributors to the activation of a Th1 response. This signaling mechanism is distinct and yet complementary to LPS-mediated T-cell activation. We suggest that this novel zymosan-induced GM-CSF-mediated signaling network may play a key role in regulating specific immune cell type activities." @default.
- W2071421038 created "2016-06-24" @default.
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- W2071421038 date "2011-07-01" @default.
- W2071421038 modified "2023-10-03" @default.
- W2071421038 title "GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells" @default.
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- W2071421038 doi "https://doi.org/10.1016/j.cyto.2011.03.017" @default.
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