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- W2071423132 abstract "Although intrathecal administration of baclofen, a selective GABAB-receptor agonist, is known to have an antinociceptive effect on various pain models, the role of presynaptic GABAB receptors in antinociception is not well characterized. In the present study, the action of baclofen on primary afferent-evoked glutamatergic excitatory transmission was examined in substantia gelatinosa (SG) neurons of an adult rat spinal cord slice with an attached dorsal root, prepared from the lumbar segment, by use of the blind whole-cell patch-clamp technique. Under the condition where a postsynaptic action of baclofen was inhibited, baclofen (1 μM) reduced the amplitudes of excitatory postsynaptic currents (EPSCs; VH=−70 mV) which were monosynaptically evoked by stimulating primary-afferent C- and/or Aδ-fibers and which were remarkably depressed by CNQX (10 μM). The identification of the C-fiber or Aδ-fiber EPSC was based on antidromic action potentials recorded from neurons of isolated dorsal root ganglia. The C-fiber EPSC was depressed in peak amplitude by baclofen (1 μM) to a larger extent than the Aδ-fiber EPSC (20 and 45% of control, respectively). Each of the baclofen actions was suppressed by a selective GABAB-receptor antagonist, CGP 35348 (50 μM). Baclofen (1 μM) did not affect a response of SG neurons to bath-applied AMPA (10 μM). These results indicate that baclofen inhibits the release of L-glutamate from Aδ and C primary-afferent terminals in the SG through the activation of GABAB receptor; this action is more effective to C-fiber than Aδ-fiber transmission. Considering that the SG is the main part of termination of Aδ- and C-fibers transmitting nociceptive information, the present finding would account for at least a part of the inhibitory action of baclofen on pain transmission." @default.
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- W2071423132 title "1410 Calbindin expression in medial geniculate neurons is regulated by acetylcholinesterase in terminals of projection fibers from the inferior colliculi in developing rats" @default.
- W2071423132 doi "https://doi.org/10.1016/0168-0102(96)89013-4" @default.
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