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- W2071424265 abstract "A 10-year-old boy (37.5 kg; body surface area 1.26m2) with osteosarcoma of the right humerus received a planned 4-hour infusion of high-dose methotrexate (16 g, 12.7 g/m(2)). His previous medical history was notable for an implanted central venous catheter placement complicated by Horner's syndrome. Renal and hepatic functions were normal at baseline. A postinfusion methotrexate concentration was uninterpretable, but the significance of this result was not initially appreciated by the treating clinicians. Over the next 48 hours, the child developed blurry vision, painful mucositis, stomatitis, and facial blistering. Reported vital signs were: BP, 121/82 mm Hg; pulse, 111/minute; respirations, 16/minute. A physical examination was consistent with the reported symptoms. The 48-hour postinfusion serum methotrexate concentration at the time of poison control center (PCC) consultation was 171 micromol/L. Language: en" @default.
- W2071424265 created "2016-06-24" @default.
- W2071424265 creator A5019962152 @default.
- W2071424265 creator A5089181636 @default.
- W2071424265 date "2008-06-01" @default.
- W2071424265 modified "2023-09-27" @default.
- W2071424265 title "Case files of the New York City Poison Control Center: Antidotal strategies for the management of methotrexate toxicity" @default.
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- W2071424265 doi "https://doi.org/10.1007/bf03160968" @default.
- W2071424265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3550133" @default.
- W2071424265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18570175" @default.
- W2071424265 hasPublicationYear "2008" @default.
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