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• W2071427306 endingPage "11080" @default.
• W2071427306 startingPage "11054" @default.
• W2071427306 abstract "Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells. Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents." @default.
• W2071427306 created "2016-06-24" @default.
• W2071427306 creator A5005517671 @default.
• W2071427306 creator A5035618234 @default.
• W2071427306 creator A5038739772 @default.
• W2071427306 date "1996-11-13" @default.
• W2071427306 modified "2023-10-16" @default.
• W2071427306 title "Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization" @default.
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• W2071427306 doi "https://doi.org/10.1021/ja961374o" @default.
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