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• W2071432007 abstract "Background. Glioma is the most malignant tumor of the central nervous system. Efforts on the development of new chemotherapy are mandatory. Andrographolide (AND), a diterpenoid lactone isolated from the Andrographis paniculata , has been shown to have antitumor activities in several types of cancer cells. Whether AND can exert its antitumor activity in glioblastoma cells remains unknown. This study examined the anticancer effects of AND, both in vitro and in vivo . Methods. Cell apoptosis was assayed by flow cytometry and nuclear staining. The signaling pathway for AND was determined by western blotting. The effects of AND on tumor growth was evaluated in a mouse model. Results and Conclusion. In vitro , with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway. In vivo , AND significantly retarded tumor growth and caused regression of well-formed tumors in vivo . Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cultured astrocyte cells, and it may serve as a potential therapeutic candidate for the treatment of glioma." @default.
• W2071432007 created "2016-06-24" @default.
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• W2071432007 date "2014-01-01" @default.
• W2071432007 modified "2023-10-18" @default.
• W2071432007 title "Andrographolide Induces Apoptosis of C6 Glioma Cells via the ERK-p53-Caspase 7-PARP Pathway" @default.
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• W2071432007 doi "https://doi.org/10.1155/2014/312847" @default.
• W2071432007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139087" @default.
• W2071432007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25162007" @default.
• W2071432007 hasPublicationYear "2014" @default.
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