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- W2071434204 abstract "For largely unknown reasons, severe diabetes mellitus in pregnant rats results in fetal growth retardation. In order to clarify the mechanism of this phenomenon, the relationship between the fetal growth and the uteroplacental blood flow, and the fetal serum insulin and IGF-1 concentrations were studied in streptozotocine-induced diabetic and control pregnant rats. As compared to control rats, diabetic rats had significantly reduced uteroplacental blood flow, and the mean body weight of the fetuses was significantly lower. Treatment of diabetic rats with an α1-blocking vasodilator, urapidil, restored uteroplacental blood flow and fetal body weight without affecting hyperglycemia. There was no significant difference between diabetic and normal rats with respect to insulin and IGF-1 concentrations in fetal plasma, although the mean value was slightly lower in the diabetic. We conclude that reduced uteroplacental blood flow is a major factor in the establishment of fetal growth retardation in diabetic pregnancies." @default.
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- W2071434204 date "1995-02-01" @default.
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- W2071434204 title "The effect of α 1-blocking vasodilator on fetal growth and uteroplacental blood flow in streptozotocin-induced diabetic rats" @default.
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- W2071434204 doi "https://doi.org/10.1016/0024-3205(95)00050-g" @default.
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