Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071444621> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2071444621 endingPage "161" @default.
- W2071444621 startingPage "157" @default.
- W2071444621 abstract "Prolyl endopeptidase (PEP, EC 3.4.21.26) is an enzyme which plays a role in the metabolism of proline-containing neuropeptides, e.g., vasopressin, substance P and thyrotropin-releasing hormone (TRH), which have been suggested to be involved in learning and memory processes. In our systematic screening for PEP inhibitors from traditional Chinese medicines, we found that MeOH extract from the underground part of Rhodiola sacra S. H. Fu shows significant inhibitory activity against PEP from Flavobacterium meningosepticum. Examination of the constituents of the extract resulted in the isolation of nineteen known compounds, identified as hydroquinone (1), 4-hydroxybenzoic acid (2), caffeic acid (3), 4-hydroxycinnamic acid (4), suberic acid (5), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 2-phenylethyl beta-D-glucopyranoside (9), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), 2-phenylethyl alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside (11), sacranoside A (12), beta-D-glucopyranosyl 4-hydroxybenzoate (13), rhodiocyanoside A (14), rhodiooctanoside (15), sarmentosin (16), heterodendrin (17), arbutin (18) and 4-O-(beta-D-glucopyranosyl)-gallic acid (19). Among these, 1, 2, 5, 8-10, 13, 16, 18 and 19 have been isolated for the first time from R. sacra, among which 5, 9, 10, 13, 16, 18 and 19 have been isolated from Rhodiola plants for the first time. On the PEP inhibition, seven compounds (6-8, 10, 12, 18, 19) showed inhibition with an 1C50 of 27.8, 487, 1.47, 0.437, 348, 391 and 215 microM, respectively. The kinetic study of these inhibitors indicated that they are noncompetitive inhibitors, except for 6 which is a competitive inhibitor." @default.
- W2071444621 created "2016-06-24" @default.
- W2071444621 creator A5025631052 @default.
- W2071444621 creator A5066590781 @default.
- W2071444621 creator A5072532166 @default.
- W2071444621 creator A5073229168 @default.
- W2071444621 creator A5081347827 @default.
- W2071444621 date "1999-01-01" @default.
- W2071444621 modified "2023-10-16" @default.
- W2071444621 title "Prolyl Endopeptidase Inhibitors from the Underground Part of Rhodiola sacra S.H.Fu." @default.
- W2071444621 doi "https://doi.org/10.1248/bpb.22.157" @default.
- W2071444621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10077434" @default.
- W2071444621 hasPublicationYear "1999" @default.
- W2071444621 type Work @default.
- W2071444621 sameAs 2071444621 @default.
- W2071444621 citedByCount "51" @default.
- W2071444621 countsByYear W20714446212012 @default.
- W2071444621 countsByYear W20714446212014 @default.
- W2071444621 countsByYear W20714446212015 @default.
- W2071444621 countsByYear W20714446212016 @default.
- W2071444621 countsByYear W20714446212018 @default.
- W2071444621 countsByYear W20714446212019 @default.
- W2071444621 countsByYear W20714446212020 @default.
- W2071444621 countsByYear W20714446212021 @default.
- W2071444621 countsByYear W20714446212022 @default.
- W2071444621 crossrefType "journal-article" @default.
- W2071444621 hasAuthorship W2071444621A5025631052 @default.
- W2071444621 hasAuthorship W2071444621A5066590781 @default.
- W2071444621 hasAuthorship W2071444621A5072532166 @default.
- W2071444621 hasAuthorship W2071444621A5073229168 @default.
- W2071444621 hasAuthorship W2071444621A5081347827 @default.
- W2071444621 hasBestOaLocation W20714446211 @default.
- W2071444621 hasConcept C181199279 @default.
- W2071444621 hasConcept C185592680 @default.
- W2071444621 hasConcept C2776775109 @default.
- W2071444621 hasConcept C2777439193 @default.
- W2071444621 hasConcept C2778004101 @default.
- W2071444621 hasConcept C2778362808 @default.
- W2071444621 hasConcept C2779526882 @default.
- W2071444621 hasConcept C2781424683 @default.
- W2071444621 hasConcept C43617362 @default.
- W2071444621 hasConcept C55493867 @default.
- W2071444621 hasConcept C71240020 @default.
- W2071444621 hasConceptScore W2071444621C181199279 @default.
- W2071444621 hasConceptScore W2071444621C185592680 @default.
- W2071444621 hasConceptScore W2071444621C2776775109 @default.
- W2071444621 hasConceptScore W2071444621C2777439193 @default.
- W2071444621 hasConceptScore W2071444621C2778004101 @default.
- W2071444621 hasConceptScore W2071444621C2778362808 @default.
- W2071444621 hasConceptScore W2071444621C2779526882 @default.
- W2071444621 hasConceptScore W2071444621C2781424683 @default.
- W2071444621 hasConceptScore W2071444621C43617362 @default.
- W2071444621 hasConceptScore W2071444621C55493867 @default.
- W2071444621 hasConceptScore W2071444621C71240020 @default.
- W2071444621 hasIssue "2" @default.
- W2071444621 hasLocation W20714446211 @default.
- W2071444621 hasLocation W20714446212 @default.
- W2071444621 hasOpenAccess W2071444621 @default.
- W2071444621 hasPrimaryLocation W20714446211 @default.
- W2071444621 hasRelatedWork W1986312167 @default.
- W2071444621 hasRelatedWork W2024606237 @default.
- W2071444621 hasRelatedWork W2034605167 @default.
- W2071444621 hasRelatedWork W2041645058 @default.
- W2071444621 hasRelatedWork W2059359154 @default.
- W2071444621 hasRelatedWork W2071444621 @default.
- W2071444621 hasRelatedWork W2081104964 @default.
- W2071444621 hasRelatedWork W2352127081 @default.
- W2071444621 hasRelatedWork W2377498555 @default.
- W2071444621 hasRelatedWork W3204999561 @default.
- W2071444621 hasVolume "22" @default.
- W2071444621 isParatext "false" @default.
- W2071444621 isRetracted "false" @default.
- W2071444621 magId "2071444621" @default.
- W2071444621 workType "article" @default.