Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071447152> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2071447152 endingPage "1076" @default.
- W2071447152 startingPage "1069" @default.
- W2071447152 abstract "To determine if aerosolized medications can be targeted to deposit in the smaller, peripheral airways or the larger, central airways of adult cystic fibrosis (CF) patients by varying particle size and inspiratory flow rate.Randomized clinical trial.Outpatient research laboratory.Nine adult patients with CF.Patients inhaled an aerosol comprised of 3.68+/-0.04 microm saline solution droplets (two visits) or 1.01+/- 0.2 microm saline solution droplets (two visits) for 30 s, starting from functional residual capacity and breathing at a slow or faster inspiratory flow rate. On all visits, the saline solution was admixed with the radioisotope (99m)Tc. Immediately after inhalation, a gamma camera recorded the deposition pattern of the radioaerosol in the lungs. Deposition images were analyzed in terms of the inner:outer zone (I:O) ratio, a measure of deposition in an inner zone (large, central airways) vs. an outer zone (small airways and alveoli).For the 3.68-microm aerosol, I:O ratios averaged 2.29+/-1.45 and 2.54+/-1.48 (p>0.05), indicating that aerosol distribution within the lungs was unchanged while breathing at 12+/-2 L/min vs. 31+/-5 L/min, respectively. For the 1.01-microm aerosol, I:O ratios averaged 2.09+/-0.96 and 3.19+/-1.95 (p<0.05), indicating that deposition was predominantly in the smaller airways while breathing at 18+/-5 L/min and in the larger airways while breathing at 38+/-8 L/min, respectively.These results suggest that the targeted delivery of an aerosol to the smaller, peripheral airways or the larger, central airways of adult CF patients may be achieved by generating an aerosol comprised of approximately 1.0-microm particles and inspiring from functional residual capacity at approximately 18 L/min and approximately 38 L/min, respectively." @default.
- W2071447152 created "2016-06-24" @default.
- W2071447152 creator A5021975422 @default.
- W2071447152 creator A5037950482 @default.
- W2071447152 creator A5052055623 @default.
- W2071447152 creator A5078993877 @default.
- W2071447152 date "2000-10-01" @default.
- W2071447152 modified "2023-10-02" @default.
- W2071447152 title "Targeting Aerosol Deposition in Patients With Cystic Fibrosis" @default.
- W2071447152 cites W1973868711 @default.
- W2071447152 cites W2003724450 @default.
- W2071447152 cites W2021308965 @default.
- W2071447152 cites W2042305464 @default.
- W2071447152 cites W2064117517 @default.
- W2071447152 cites W2079185821 @default.
- W2071447152 cites W2139123153 @default.
- W2071447152 cites W2590124738 @default.
- W2071447152 cites W4236247973 @default.
- W2071447152 doi "https://doi.org/10.1378/chest.118.4.1069" @default.
- W2071447152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11035679" @default.
- W2071447152 hasPublicationYear "2000" @default.
- W2071447152 type Work @default.
- W2071447152 sameAs 2071447152 @default.
- W2071447152 citedByCount "66" @default.
- W2071447152 countsByYear W20714471522012 @default.
- W2071447152 countsByYear W20714471522013 @default.
- W2071447152 countsByYear W20714471522014 @default.
- W2071447152 countsByYear W20714471522015 @default.
- W2071447152 countsByYear W20714471522016 @default.
- W2071447152 countsByYear W20714471522018 @default.
- W2071447152 countsByYear W20714471522019 @default.
- W2071447152 countsByYear W20714471522020 @default.
- W2071447152 countsByYear W20714471522021 @default.
- W2071447152 countsByYear W20714471522023 @default.
- W2071447152 crossrefType "journal-article" @default.
- W2071447152 hasAuthorship W2071447152A5021975422 @default.
- W2071447152 hasAuthorship W2071447152A5037950482 @default.
- W2071447152 hasAuthorship W2071447152A5052055623 @default.
- W2071447152 hasAuthorship W2071447152A5078993877 @default.
- W2071447152 hasConcept C126322002 @default.
- W2071447152 hasConcept C142724271 @default.
- W2071447152 hasConcept C151730666 @default.
- W2071447152 hasConcept C178790620 @default.
- W2071447152 hasConcept C185592680 @default.
- W2071447152 hasConcept C2776938444 @default.
- W2071447152 hasConcept C2776954882 @default.
- W2071447152 hasConcept C2777397205 @default.
- W2071447152 hasConcept C2779345167 @default.
- W2071447152 hasConcept C2816523 @default.
- W2071447152 hasConcept C42219234 @default.
- W2071447152 hasConcept C64297162 @default.
- W2071447152 hasConcept C71924100 @default.
- W2071447152 hasConcept C86803240 @default.
- W2071447152 hasConceptScore W2071447152C126322002 @default.
- W2071447152 hasConceptScore W2071447152C142724271 @default.
- W2071447152 hasConceptScore W2071447152C151730666 @default.
- W2071447152 hasConceptScore W2071447152C178790620 @default.
- W2071447152 hasConceptScore W2071447152C185592680 @default.
- W2071447152 hasConceptScore W2071447152C2776938444 @default.
- W2071447152 hasConceptScore W2071447152C2776954882 @default.
- W2071447152 hasConceptScore W2071447152C2777397205 @default.
- W2071447152 hasConceptScore W2071447152C2779345167 @default.
- W2071447152 hasConceptScore W2071447152C2816523 @default.
- W2071447152 hasConceptScore W2071447152C42219234 @default.
- W2071447152 hasConceptScore W2071447152C64297162 @default.
- W2071447152 hasConceptScore W2071447152C71924100 @default.
- W2071447152 hasConceptScore W2071447152C86803240 @default.
- W2071447152 hasIssue "4" @default.
- W2071447152 hasLocation W20714471521 @default.
- W2071447152 hasLocation W20714471522 @default.
- W2071447152 hasOpenAccess W2071447152 @default.
- W2071447152 hasPrimaryLocation W20714471521 @default.
- W2071447152 hasRelatedWork W183302643 @default.
- W2071447152 hasRelatedWork W1989116413 @default.
- W2071447152 hasRelatedWork W2011809459 @default.
- W2071447152 hasRelatedWork W2019092074 @default.
- W2071447152 hasRelatedWork W2072961217 @default.
- W2071447152 hasRelatedWork W2197366964 @default.
- W2071447152 hasRelatedWork W2410986564 @default.
- W2071447152 hasRelatedWork W2416854703 @default.
- W2071447152 hasRelatedWork W2418502454 @default.
- W2071447152 hasRelatedWork W2978896423 @default.
- W2071447152 hasVolume "118" @default.
- W2071447152 isParatext "false" @default.
- W2071447152 isRetracted "false" @default.
- W2071447152 magId "2071447152" @default.
- W2071447152 workType "article" @default.