Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071447315> ?p ?o ?g. }
- W2071447315 endingPage "898" @default.
- W2071447315 startingPage "891" @default.
- W2071447315 abstract "Objectives. The objectives of this study were 1) to define in an experimental model of heart failure the time course of changes in plasma brain natriuretic peptide concentrations during the development of and recovery from heart failure, and 2) to relate these changes to changes in atrial natriuretic peptide concentration and hemodynamic status. Background. Brain natriuretic peptide is a circulating peptide with homology to atrial natriuretic peptide. However, unlike the latter, its changes during heart failure and its relation to cardiac filling pressures have not been studied. Methods. Eight male mongrel dogs underwent right ventricular pacing at 250 beats/min for 3 weeks until heart failure occurred and were followed up during recovery for 4 weeks after cessation of pacing. Results. Heart failure was characterized by an increase in both left ventricular end-diastolic pressure (6.6 ± 4.1 mm Hg at the control measurements to 35.1 ± 5.9 mm Hg at 3 weeks, p < 0.01) and right atrial pressure (6.7 ± 1.1 to 11.4 ± 2.1 mm Hg, p < 0.01). Recovery was accompanied by a return of cardiac filling pressures to control level. The time course of change of arterial plasma brain natriuretic peptide concentration was similar to that of atrial natriuretic peptide. Plasma concentrations of both peptides increased after 1 week of pacing (16 ± 4 pg/ml at the control measurement to 59 ± 20 pg/ml at 1 week, p < 0.001 for brain natriuretic peptide and 84 ± 55 to 856 ± 295 pg/ml, p < 0.001 for atrial natriuretic peptide). The level of both peptides then stayed level with no further increase at 3 weeks and returned to the control value by 4 weeks of recovery. There was an excellent correlation between plasma concentrations of the two peptides (r = 0.86, p < 0.001) and between the two peptides and cardiac filling pressures. However, compared with atrial natriuretic peptide, plasma brain natriuretic peptide concentration had a smaller percent increase during evolving heart failure and a slower rate of decline at recovery. Conclusions. Brain and atrial natriuretic peptide constitute a dual natriuretic system and are both responsive to changes in cardiac filling pressures in heart failure. However, brain natriuretic peptide appears to be less responsive than atrial natriuretic peptide." @default.
- W2071447315 created "2016-06-24" @default.
- W2071447315 creator A5002135839 @default.
- W2071447315 creator A5025678566 @default.
- W2071447315 creator A5037527199 @default.
- W2071447315 creator A5050165617 @default.
- W2071447315 creator A5068077402 @default.
- W2071447315 date "1993-09-01" @default.
- W2071447315 modified "2023-10-01" @default.
- W2071447315 title "Dual natriuretic peptide system in experimental heart failure" @default.
- W2071447315 cites W1965293430 @default.
- W2071447315 cites W1966774601 @default.
- W2071447315 cites W1972320719 @default.
- W2071447315 cites W1975728622 @default.
- W2071447315 cites W1979659033 @default.
- W2071447315 cites W1980929921 @default.
- W2071447315 cites W1981438457 @default.
- W2071447315 cites W1984032648 @default.
- W2071447315 cites W1989543418 @default.
- W2071447315 cites W1997272952 @default.
- W2071447315 cites W2013021063 @default.
- W2071447315 cites W2014753402 @default.
- W2071447315 cites W2024332037 @default.
- W2071447315 cites W2025109929 @default.
- W2071447315 cites W2028389385 @default.
- W2071447315 cites W2028869258 @default.
- W2071447315 cites W2038914837 @default.
- W2071447315 cites W2039043892 @default.
- W2071447315 cites W2041179424 @default.
- W2071447315 cites W2045076976 @default.
- W2071447315 cites W2046709360 @default.
- W2071447315 cites W2052097767 @default.
- W2071447315 cites W2054423282 @default.
- W2071447315 cites W2054649519 @default.
- W2071447315 cites W2063762994 @default.
- W2071447315 cites W2070642516 @default.
- W2071447315 cites W2099601233 @default.
- W2071447315 cites W2110614029 @default.
- W2071447315 cites W2115335174 @default.
- W2071447315 cites W2120088785 @default.
- W2071447315 cites W2126548160 @default.
- W2071447315 cites W2135900165 @default.
- W2071447315 cites W2155322080 @default.
- W2071447315 cites W2166079697 @default.
- W2071447315 cites W2257203876 @default.
- W2071447315 doi "https://doi.org/10.1016/0735-1097(93)90208-i" @default.
- W2071447315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8354829" @default.
- W2071447315 hasPublicationYear "1993" @default.
- W2071447315 type Work @default.
- W2071447315 sameAs 2071447315 @default.
- W2071447315 citedByCount "43" @default.
- W2071447315 countsByYear W20714473152012 @default.
- W2071447315 countsByYear W20714473152013 @default.
- W2071447315 countsByYear W20714473152014 @default.
- W2071447315 countsByYear W20714473152015 @default.
- W2071447315 countsByYear W20714473152017 @default.
- W2071447315 countsByYear W20714473152019 @default.
- W2071447315 countsByYear W20714473152020 @default.
- W2071447315 countsByYear W20714473152021 @default.
- W2071447315 countsByYear W20714473152022 @default.
- W2071447315 countsByYear W20714473152023 @default.
- W2071447315 crossrefType "journal-article" @default.
- W2071447315 hasAuthorship W2071447315A5002135839 @default.
- W2071447315 hasAuthorship W2071447315A5025678566 @default.
- W2071447315 hasAuthorship W2071447315A5037527199 @default.
- W2071447315 hasAuthorship W2071447315A5050165617 @default.
- W2071447315 hasAuthorship W2071447315A5068077402 @default.
- W2071447315 hasBestOaLocation W20714473151 @default.
- W2071447315 hasConcept C126322002 @default.
- W2071447315 hasConcept C139940330 @default.
- W2071447315 hasConcept C164705383 @default.
- W2071447315 hasConcept C178853913 @default.
- W2071447315 hasConcept C2775846464 @default.
- W2071447315 hasConcept C2775915353 @default.
- W2071447315 hasConcept C2778069365 @default.
- W2071447315 hasConcept C2778198053 @default.
- W2071447315 hasConcept C57900726 @default.
- W2071447315 hasConcept C71924100 @default.
- W2071447315 hasConcept C84393581 @default.
- W2071447315 hasConceptScore W2071447315C126322002 @default.
- W2071447315 hasConceptScore W2071447315C139940330 @default.
- W2071447315 hasConceptScore W2071447315C164705383 @default.
- W2071447315 hasConceptScore W2071447315C178853913 @default.
- W2071447315 hasConceptScore W2071447315C2775846464 @default.
- W2071447315 hasConceptScore W2071447315C2775915353 @default.
- W2071447315 hasConceptScore W2071447315C2778069365 @default.
- W2071447315 hasConceptScore W2071447315C2778198053 @default.
- W2071447315 hasConceptScore W2071447315C57900726 @default.
- W2071447315 hasConceptScore W2071447315C71924100 @default.
- W2071447315 hasConceptScore W2071447315C84393581 @default.
- W2071447315 hasIssue "3" @default.
- W2071447315 hasLocation W20714473151 @default.
- W2071447315 hasLocation W20714473152 @default.
- W2071447315 hasOpenAccess W2071447315 @default.
- W2071447315 hasPrimaryLocation W20714473151 @default.
- W2071447315 hasRelatedWork W2009748564 @default.
- W2071447315 hasRelatedWork W2115795314 @default.
- W2071447315 hasRelatedWork W2328354663 @default.