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• W2071451650 startingPage "35" @default.
• W2071451650 abstract "The conjugation of the cationic antimicrobial peptide, apidaecin Ib, to the anionic photosensitizer, 5(4'-carboxyphenyl)-10,15,20-triphenylporphyrin (cTPP), afforded a new antibacterial agent effective, under light activation, against both Gram-positive and Gram-negative bacteria. At low concentrations (1.5-15 μM) the conjugate was able to reduce the survival of Escherichia coli cells by 3-4 log10, and most notably, it resulted photoactive also against hard-to-treat Pseudomonas aeruginosa, although at higher concentration (60 μM). Under similar conditions, the photosensitizer alone was only photoactive against Staphylococcus aureus while the unconjugated peptide was inactive against all the bacterial strains tested. This study shows the possibility of obtaining new broad-spectrum apidaecin-photosensitizer conjugates with potent antibacterial activity." @default.
• W2071451650 created "2016-06-24" @default.
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• W2071451650 date "2010-02-01" @default.
• W2071451650 modified "2023-10-14" @default.
• W2071451650 title "Porphyrin−Apidaecin Conjugate as a New Broad Spectrum Antibacterial Agent" @default.
• W2071451650 cites W1970798262 @default.
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• W2071451650 doi "https://doi.org/10.1021/ml900021y" @default.
• W2071451650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4007951" @default.
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