Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071458877> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2071458877 endingPage "256" @default.
- W2071458877 startingPage "249" @default.
- W2071458877 abstract "To explain the low transmissibility and pathogenicity of HIV-2 infection’s plasma viral loads in both HIV-1- and HIV-2-infected persons were compared by using the polymerase chain reaction (PCR)-based Amp-RT assay to measure levels of reverse transcriptase (RT) activity. The study comprised a total of 155 HIV-infectedpeople including 58 who were infected with HIV-2 with CD4+ cell counts <500 x 106/L (n = 15), CD4+ cell counts >500 × 106/L (n = 26), or with tuberculosis (TB; n = 17), and 97 HIV-1-infected people with CD4+ cell counts <500 × 106/L (n = 32), CD4+ cell counts >500 × 106/L (n = 25), or TB (n = 40). Among persons with CD4+ cell counts <500 × 106/L, 11 (73.3%) of 15 HIV-2-infected persons had detectable plasma RT activity compared with 25 (78.1%) of 32 HIV-1-infected persons (p = .725). However, the median HIV-2 plasma RT activity in this group was significantly lower (2561 × 10-10 U/ml; p = .036; detectable range, 1712-644,868 x 10”-10 U/ml) than the RT activity of HIV-1-infected persons with similar CD4+ cell counts (13,241 x 10-10 U/ml; detectable range, 8482-1,478,880 × 10-10 U/ml). Among TB patients, 10 (58.8%) of 17 HIV-2-infected persons had detectable plasma RT activity compared with 30 (75%) of 40 HIV-1-infected persons (p = .342). In contrast, among patients with CD4+ cell counts >500 × 106/L, none of 26 HIV-2-infected persons had detectable RT activity compared with 13 (52%) of 25 HIV-1-infected persons (p < .001). Our data suggest that unlike HIV-1 infection, HIV-2 infections with CD4+ cell counts >500 × 106/L are associated with a low level of viral replication, which may explain the longer clinical latency and lower transmissibility seen in HIV-2 infection." @default.
- W2071458877 created "2016-06-24" @default.
- W2071458877 creator A5026757492 @default.
- W2071458877 creator A5033773018 @default.
- W2071458877 creator A5039130059 @default.
- W2071458877 creator A5040895608 @default.
- W2071458877 creator A5043242107 @default.
- W2071458877 date "2000-07-01" @default.
- W2071458877 modified "2023-09-26" @default.
- W2071458877 title "Prenatal Zidovudine Use and Congenital Anomalies in a Medicaid Population" @default.
- W2071458877 cites W1984230344 @default.
- W2071458877 cites W1988744335 @default.
- W2071458877 cites W2012564542 @default.
- W2071458877 cites W2018685007 @default.
- W2071458877 cites W2024128336 @default.
- W2071458877 cites W2042538519 @default.
- W2071458877 cites W2086040638 @default.
- W2071458877 cites W2096770291 @default.
- W2071458877 cites W2102919880 @default.
- W2071458877 cites W2104853744 @default.
- W2071458877 cites W2114790957 @default.
- W2071458877 cites W2118565589 @default.
- W2071458877 cites W2316970929 @default.
- W2071458877 cites W2317084073 @default.
- W2071458877 cites W2337158409 @default.
- W2071458877 cites W4248328089 @default.
- W2071458877 doi "https://doi.org/10.1097/00126334-200007010-00009" @default.
- W2071458877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10969349" @default.
- W2071458877 hasPublicationYear "2000" @default.
- W2071458877 type Work @default.
- W2071458877 sameAs 2071458877 @default.
- W2071458877 citedByCount "25" @default.
- W2071458877 countsByYear W20714588772012 @default.
- W2071458877 countsByYear W20714588772013 @default.
- W2071458877 countsByYear W20714588772014 @default.
- W2071458877 countsByYear W20714588772015 @default.
- W2071458877 countsByYear W20714588772016 @default.
- W2071458877 countsByYear W20714588772017 @default.
- W2071458877 countsByYear W20714588772018 @default.
- W2071458877 countsByYear W20714588772022 @default.
- W2071458877 crossrefType "journal-article" @default.
- W2071458877 hasAuthorship W2071458877A5026757492 @default.
- W2071458877 hasAuthorship W2071458877A5033773018 @default.
- W2071458877 hasAuthorship W2071458877A5039130059 @default.
- W2071458877 hasAuthorship W2071458877A5040895608 @default.
- W2071458877 hasAuthorship W2071458877A5043242107 @default.
- W2071458877 hasBestOaLocation W20714588771 @default.
- W2071458877 hasConcept C126322002 @default.
- W2071458877 hasConcept C142462285 @default.
- W2071458877 hasConcept C142724271 @default.
- W2071458877 hasConcept C159047783 @default.
- W2071458877 hasConcept C203014093 @default.
- W2071458877 hasConcept C2779690655 @default.
- W2071458877 hasConcept C2780216070 @default.
- W2071458877 hasConcept C2780727368 @default.
- W2071458877 hasConcept C2781069245 @default.
- W2071458877 hasConcept C2908647359 @default.
- W2071458877 hasConcept C3013748606 @default.
- W2071458877 hasConcept C71924100 @default.
- W2071458877 hasConcept C99454951 @default.
- W2071458877 hasConceptScore W2071458877C126322002 @default.
- W2071458877 hasConceptScore W2071458877C142462285 @default.
- W2071458877 hasConceptScore W2071458877C142724271 @default.
- W2071458877 hasConceptScore W2071458877C159047783 @default.
- W2071458877 hasConceptScore W2071458877C203014093 @default.
- W2071458877 hasConceptScore W2071458877C2779690655 @default.
- W2071458877 hasConceptScore W2071458877C2780216070 @default.
- W2071458877 hasConceptScore W2071458877C2780727368 @default.
- W2071458877 hasConceptScore W2071458877C2781069245 @default.
- W2071458877 hasConceptScore W2071458877C2908647359 @default.
- W2071458877 hasConceptScore W2071458877C3013748606 @default.
- W2071458877 hasConceptScore W2071458877C71924100 @default.
- W2071458877 hasConceptScore W2071458877C99454951 @default.
- W2071458877 hasIssue "3" @default.
- W2071458877 hasLocation W20714588771 @default.
- W2071458877 hasLocation W20714588772 @default.
- W2071458877 hasLocation W20714588773 @default.
- W2071458877 hasOpenAccess W2071458877 @default.
- W2071458877 hasPrimaryLocation W20714588771 @default.
- W2071458877 hasRelatedWork W1978003867 @default.
- W2071458877 hasRelatedWork W1985771280 @default.
- W2071458877 hasRelatedWork W1988777930 @default.
- W2071458877 hasRelatedWork W1999388526 @default.
- W2071458877 hasRelatedWork W2016468531 @default.
- W2071458877 hasRelatedWork W2140412799 @default.
- W2071458877 hasRelatedWork W2313400264 @default.
- W2071458877 hasRelatedWork W2315233653 @default.
- W2071458877 hasRelatedWork W2414737159 @default.
- W2071458877 hasRelatedWork W2442654169 @default.
- W2071458877 hasVolume "24" @default.
- W2071458877 isParatext "false" @default.
- W2071458877 isRetracted "false" @default.
- W2071458877 magId "2071458877" @default.
- W2071458877 workType "article" @default.