FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071462924> ?p ?o ?g. }

• W2071462924 endingPage "80" @default.
• W2071462924 startingPage "72" @default.
• W2071462924 abstract "We describe for the first time the successful organ culture, in a serum-free chemically defined medium, of hind limb buds from stage 54/55 Xenopus laevis tadpoles in which 2 × 10−9 M triiodothyronine (T3) precociously induces morphogenesis to give rise to morphologically normal limbs within 7 days. It was important to retain the mesenchymal tissue joining the two limb buds in order to obtain limb development in culture. T3 added to tail explants from the same larvae, cultured in parallel with limb buds, induced regression and cell loss at rates comparable to those seen during T3-induced metamorphosis in intact tadpoles. We also demonstrate for the first time that 0.2 units of prolactin (PRL) added at the same time as 2 × 10−9 M T3 totally blocked both limb development and tail regression over 8 days in culture. When added after T3 had initiated its metamorphic action, PRL arrested further morphogenesis and regression of these two tissues, respectively. Retinoic acid at 10−7 M had only a marginal effect. Histological examination showed that T3 added to limb buds produced normal chondrogenesis and osteogenesis in vitro as well as skin, muscle, and digit formation, while it produced a rapid and marked histolysis of fin and connective tissue of the tail. The ease of hormonally manipulating both morphogenesis and cell death in culture in opposite directions offers a simple, effective model system for molecular analysis of mechanisms underlying hormone-regulated postembryonic developmental processes." @default.
• W2071462924 created "2016-06-24" @default.
• W2071462924 creator A5017445317 @default.
• W2071462924 creator A5060656754 @default.
• W2071462924 creator A5085525308 @default.
• W2071462924 date "1991-07-01" @default.
• W2071462924 modified "2023-10-18" @default.
• W2071462924 title "Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues" @default.
• W2071462924 cites W1180108146 @default.
• W2071462924 cites W1487696856 @default.
• W2071462924 cites W1963491544 @default.
• W2071462924 cites W1967080529 @default.
• W2071462924 cites W1986379734 @default.
• W2071462924 cites W1994817327 @default.
• W2071462924 cites W2007648963 @default.
• W2071462924 cites W2015351895 @default.
• W2071462924 cites W2026399172 @default.
• W2071462924 cites W2036269615 @default.
• W2071462924 cites W2066219780 @default.
• W2071462924 cites W2068069263 @default.
• W2071462924 cites W2074834727 @default.
• W2071462924 cites W2091841768 @default.
• W2071462924 cites W2094544625 @default.
• W2071462924 cites W2100407879 @default.
• W2071462924 cites W2119709540 @default.
• W2071462924 cites W2130929794 @default.
• W2071462924 cites W2142020719 @default.
• W2071462924 cites W2174542542 @default.
• W2071462924 cites W2409953317 @default.
• W2071462924 doi "https://doi.org/10.1016/0012-1606(91)90447-b" @default.
• W2071462924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2060712" @default.
• W2071462924 hasPublicationYear "1991" @default.
• W2071462924 type Work @default.
• W2071462924 sameAs 2071462924 @default.
• W2071462924 citedByCount "123" @default.
• W2071462924 countsByYear W20714629242012 @default.
• W2071462924 countsByYear W20714629242013 @default.
• W2071462924 countsByYear W20714629242016 @default.
• W2071462924 countsByYear W20714629242017 @default.
• W2071462924 countsByYear W20714629242019 @default.
• W2071462924 countsByYear W20714629242020 @default.
• W2071462924 countsByYear W20714629242021 @default.
• W2071462924 countsByYear W20714629242022 @default.
• W2071462924 countsByYear W20714629242023 @default.
• W2071462924 crossrefType "journal-article" @default.
• W2071462924 hasAuthorship W2071462924A5017445317 @default.
• W2071462924 hasAuthorship W2071462924A5060656754 @default.
• W2071462924 hasAuthorship W2071462924A5085525308 @default.
• W2071462924 hasConcept C104317684 @default.
• W2071462924 hasConcept C105702510 @default.
• W2071462924 hasConcept C126322002 @default.
• W2071462924 hasConcept C134018914 @default.
• W2071462924 hasConcept C136397037 @default.
• W2071462924 hasConcept C157890192 @default.
• W2071462924 hasConcept C173758957 @default.
• W2071462924 hasConcept C196843134 @default.
• W2071462924 hasConcept C202751555 @default.
• W2071462924 hasConcept C25770073 @default.
• W2071462924 hasConcept C2778288131 @default.
• W2071462924 hasConcept C2779064019 @default.
• W2071462924 hasConcept C2779535977 @default.
• W2071462924 hasConcept C2781121885 @default.
• W2071462924 hasConcept C28483552 @default.
• W2071462924 hasConcept C40692019 @default.
• W2071462924 hasConcept C54355233 @default.
• W2071462924 hasConcept C59822182 @default.
• W2071462924 hasConcept C71315377 @default.
• W2071462924 hasConcept C71924100 @default.
• W2071462924 hasConcept C81885089 @default.
• W2071462924 hasConcept C86803240 @default.
• W2071462924 hasConcept C90703135 @default.
• W2071462924 hasConcept C95444343 @default.
• W2071462924 hasConceptScore W2071462924C104317684 @default.
• W2071462924 hasConceptScore W2071462924C105702510 @default.
• W2071462924 hasConceptScore W2071462924C126322002 @default.
• W2071462924 hasConceptScore W2071462924C134018914 @default.
• W2071462924 hasConceptScore W2071462924C136397037 @default.
• W2071462924 hasConceptScore W2071462924C157890192 @default.
• W2071462924 hasConceptScore W2071462924C173758957 @default.
• W2071462924 hasConceptScore W2071462924C196843134 @default.
• W2071462924 hasConceptScore W2071462924C202751555 @default.
• W2071462924 hasConceptScore W2071462924C25770073 @default.
• W2071462924 hasConceptScore W2071462924C2778288131 @default.
• W2071462924 hasConceptScore W2071462924C2779064019 @default.
• W2071462924 hasConceptScore W2071462924C2779535977 @default.
• W2071462924 hasConceptScore W2071462924C2781121885 @default.
• W2071462924 hasConceptScore W2071462924C28483552 @default.
• W2071462924 hasConceptScore W2071462924C40692019 @default.
• W2071462924 hasConceptScore W2071462924C54355233 @default.
• W2071462924 hasConceptScore W2071462924C59822182 @default.
• W2071462924 hasConceptScore W2071462924C71315377 @default.
• W2071462924 hasConceptScore W2071462924C71924100 @default.
• W2071462924 hasConceptScore W2071462924C81885089 @default.
• W2071462924 hasConceptScore W2071462924C86803240 @default.
• W2071462924 hasConceptScore W2071462924C90703135 @default.
• W2071462924 hasConceptScore W2071462924C95444343 @default.
• W2071462924 hasIssue "1" @default.
• W2071462924 hasLocation W20714629241 @default.

• next