Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071465106> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2071465106 endingPage "477" @default.
- W2071465106 startingPage "471" @default.
- W2071465106 abstract "A novel experimental model of submassive liver necrosis with impaired regeneration has been established. A novel lipid A analogue, FS-112, was injected intravenously into male BALB/c mice, followed 2 days later by a 70% partial hepatectomy. Over the next 9 days, mice became severely jaundiced, with a peak total bilirubin (TBil) concentration of (mean±s.d.) 12.9±2.1 mg/dL 7 days postoperatively. In contrast, the TBil concentration in vehicle-treated mice remained less than 2 mg/dL. Significant elevations of L-alanine:2-oxoglutarate aminotransferase (ALT) were also observed 3–7 days after the operation in mice pretreated with FS-112, compared with mice pretreated with the vehicle. Submassive liver necrosis was observed with extensive mononuclear cell infiltration in mice treated with FS-112 and subjected to partial hepatectomy. Furthermore, both the BrdU and the proliferating cell nuclear antigen (PCNA) labelling index (LI) 1 day following partial hepatectomy in mice pretreated with FS-112 (8.6±4.3 and 7.9±4.2%, respectively) were significantly lower than levels in vehicletreated mice (25.8±3.8 and 26.5±10.5%, respectively). The time course of changes in the BrdU LI in liver specimens from mice treated with both FS-112 and partial hepatectomy did not increase, even 3, 5, and 7 days postoperatively. Excellent liver regeneration with a PCNA LI 10-fold higher than the resting level was observed in mice treated with D-galactosamine hydrochloride. These results strongly suggest that this animal model of submassive liver necrosis may be suitable for clarifying the mechanisms of impaired liver cell regeneration often seen in fulminant hepatitis." @default.
- W2071465106 created "2016-06-24" @default.
- W2071465106 creator A5010056221 @default.
- W2071465106 creator A5017053700 @default.
- W2071465106 creator A5020277239 @default.
- W2071465106 creator A5033926731 @default.
- W2071465106 creator A5041284607 @default.
- W2071465106 creator A5052708402 @default.
- W2071465106 date "1996-05-01" @default.
- W2071465106 modified "2023-10-18" @default.
- W2071465106 title "Treatment with a novel lipid A analogue, FS-112, and partial hepatectomy causes submassive liver necrosis and impaired liver regeneration in mice" @default.
- W2071465106 cites W1537701079 @default.
- W2071465106 cites W1548277098 @default.
- W2071465106 cites W1571858920 @default.
- W2071465106 cites W1970136580 @default.
- W2071465106 cites W1971911112 @default.
- W2071465106 cites W2031468048 @default.
- W2071465106 cites W2031504305 @default.
- W2071465106 cites W2049334700 @default.
- W2071465106 cites W2097662759 @default.
- W2071465106 cites W2105843228 @default.
- W2071465106 cites W2120621148 @default.
- W2071465106 cites W2126486896 @default.
- W2071465106 cites W2136617001 @default.
- W2071465106 cites W4244661751 @default.
- W2071465106 doi "https://doi.org/10.1111/j.1440-1746.1996.tb00293.x" @default.
- W2071465106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8743920" @default.
- W2071465106 hasPublicationYear "1996" @default.
- W2071465106 type Work @default.
- W2071465106 sameAs 2071465106 @default.
- W2071465106 citedByCount "2" @default.
- W2071465106 crossrefType "journal-article" @default.
- W2071465106 hasAuthorship W2071465106A5010056221 @default.
- W2071465106 hasAuthorship W2071465106A5017053700 @default.
- W2071465106 hasAuthorship W2071465106A5020277239 @default.
- W2071465106 hasAuthorship W2071465106A5033926731 @default.
- W2071465106 hasAuthorship W2071465106A5041284607 @default.
- W2071465106 hasAuthorship W2071465106A5052708402 @default.
- W2071465106 hasConcept C126322002 @default.
- W2071465106 hasConcept C134018914 @default.
- W2071465106 hasConcept C141071460 @default.
- W2071465106 hasConcept C142724271 @default.
- W2071465106 hasConcept C159110652 @default.
- W2071465106 hasConcept C171056886 @default.
- W2071465106 hasConcept C190283241 @default.
- W2071465106 hasConcept C204232928 @default.
- W2071465106 hasConcept C2776637226 @default.
- W2071465106 hasConcept C2776795407 @default.
- W2071465106 hasConcept C2776909242 @default.
- W2071465106 hasConcept C2777513400 @default.
- W2071465106 hasConcept C34688535 @default.
- W2071465106 hasConcept C503630168 @default.
- W2071465106 hasConcept C55493867 @default.
- W2071465106 hasConcept C71924100 @default.
- W2071465106 hasConcept C86803240 @default.
- W2071465106 hasConcept C95444343 @default.
- W2071465106 hasConceptScore W2071465106C126322002 @default.
- W2071465106 hasConceptScore W2071465106C134018914 @default.
- W2071465106 hasConceptScore W2071465106C141071460 @default.
- W2071465106 hasConceptScore W2071465106C142724271 @default.
- W2071465106 hasConceptScore W2071465106C159110652 @default.
- W2071465106 hasConceptScore W2071465106C171056886 @default.
- W2071465106 hasConceptScore W2071465106C190283241 @default.
- W2071465106 hasConceptScore W2071465106C204232928 @default.
- W2071465106 hasConceptScore W2071465106C2776637226 @default.
- W2071465106 hasConceptScore W2071465106C2776795407 @default.
- W2071465106 hasConceptScore W2071465106C2776909242 @default.
- W2071465106 hasConceptScore W2071465106C2777513400 @default.
- W2071465106 hasConceptScore W2071465106C34688535 @default.
- W2071465106 hasConceptScore W2071465106C503630168 @default.
- W2071465106 hasConceptScore W2071465106C55493867 @default.
- W2071465106 hasConceptScore W2071465106C71924100 @default.
- W2071465106 hasConceptScore W2071465106C86803240 @default.
- W2071465106 hasConceptScore W2071465106C95444343 @default.
- W2071465106 hasIssue "5" @default.
- W2071465106 hasLocation W20714651061 @default.
- W2071465106 hasLocation W20714651062 @default.
- W2071465106 hasOpenAccess W2071465106 @default.
- W2071465106 hasPrimaryLocation W20714651061 @default.
- W2071465106 hasRelatedWork W2017177725 @default.
- W2071465106 hasRelatedWork W2057093021 @default.
- W2071465106 hasRelatedWork W2071465106 @default.
- W2071465106 hasRelatedWork W2356060053 @default.
- W2071465106 hasRelatedWork W2371667678 @default.
- W2071465106 hasRelatedWork W2386923776 @default.
- W2071465106 hasRelatedWork W2394100484 @default.
- W2071465106 hasRelatedWork W2464736647 @default.
- W2071465106 hasRelatedWork W2895427826 @default.
- W2071465106 hasRelatedWork W3031552772 @default.
- W2071465106 hasVolume "11" @default.
- W2071465106 isParatext "false" @default.
- W2071465106 isRetracted "false" @default.
- W2071465106 magId "2071465106" @default.
- W2071465106 workType "article" @default.