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- W2071474311 abstract "Capillary high-performance liquid chromatography (HPLC; 300 microm i.d.) coupled to tandem mass spectrometry has been used to determine the concentration of 4-hydroxytamoxifen in mouse plasma in the pg/mL range following the administration of Tamoxifen. A limit of quantification (LOQ) of 100 pg/mL was achieved using only 25 microL of plasma. The on-column sensitivity was determined to be 100 fg. The column performance was determined isocratically before and after the assay and showed only a 15% reduction in performance after 70 injections of plasma extract. No significant peak band broadening was observed due to the mass spectrometer interface using a standard TurboIonspray source." @default.
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- W2071474311 date "2001-01-30" @default.
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- W2071474311 title "Determination of 4-hydroxytamoxifen in mouse plasma in the?pg/mL range by gradient capillary liquid chromatography/tandem mass spectrometry" @default.
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- W2071474311 doi "https://doi.org/10.1002/rcm.225" @default.
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