Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071493374> ?p ?o ?g. }
- W2071493374 endingPage "e90696" @default.
- W2071493374 startingPage "e90696" @default.
- W2071493374 abstract "The conversion of white adipose to the highly thermogenic beige adipose tissue has been proposed as a potential strategy to counter the unfavorable consequences of obesity. Three regulators of this conversion have recently emerged but information regarding their control is limited, and contradictory. We present two studies examining the control of these regulators. Study 1: In 10 young men, the plasma concentrations of irisin and fibroblast growth factor 21 (FGF21) were determined prior to and during activation of the sympathetic nervous system via hypoxic gas breathing (FIO2 = 0.11). The measurements were performed twice, once with and once without prior/concurrent sympathetic inhibition via transdermal clonidine administration. FGF21 was unaffected by basal sympathetic inhibition (338±113 vs. 295±80 pg/mL; P = 0.43; mean±SE), but was increased during hypoxia mediated sympathetic activation (368±135); this response was abrogated (P = 0.035) with clonidine (269±93). Irisin was unaffected by sympathetic inhibition and/or hypoxia (P>0.21). Study 2: The plasma concentration of irisin and FGF21, and the skeletal muscle protein content of fibronectin type III domain containing 5 (FNDC5) was determined in 19 young adults prior to and following three weeks of sprint interval training (SIT). SIT decreased FGF21 (338±78 vs. 251±36; P = 0.046) but did not affect FNDC5 (P = 0.79). Irisin was decreased in males (127±18 vs. 90±23 ng/mL; P = 0.045) and increased in females (139±14 vs. 170±18). Collectively, these data suggest a potential regulatory role of acute sympathetic activation pertaining to the browning of white adipose; further, there appears to be a sexual dimorphic response of irisin to SIT." @default.
- W2071493374 created "2016-06-24" @default.
- W2071493374 creator A5007218090 @default.
- W2071493374 creator A5014957436 @default.
- W2071493374 creator A5018715142 @default.
- W2071493374 creator A5026110940 @default.
- W2071493374 creator A5026242942 @default.
- W2071493374 creator A5048087861 @default.
- W2071493374 creator A5057335388 @default.
- W2071493374 creator A5065971326 @default.
- W2071493374 creator A5072585226 @default.
- W2071493374 creator A5078763142 @default.
- W2071493374 creator A5080880149 @default.
- W2071493374 creator A5085033007 @default.
- W2071493374 creator A5089824584 @default.
- W2071493374 date "2014-03-06" @default.
- W2071493374 modified "2023-10-03" @default.
- W2071493374 title "Regulators of Human White Adipose Browning: Evidence for Sympathetic Control and Sexual Dimorphic Responses to Sprint Interval Training" @default.
- W2071493374 cites W1556990199 @default.
- W2071493374 cites W1597933301 @default.
- W2071493374 cites W1932144823 @default.
- W2071493374 cites W1967485751 @default.
- W2071493374 cites W1986602268 @default.
- W2071493374 cites W1995004764 @default.
- W2071493374 cites W2000665430 @default.
- W2071493374 cites W2003495422 @default.
- W2071493374 cites W2005827500 @default.
- W2071493374 cites W2006024610 @default.
- W2071493374 cites W2008675205 @default.
- W2071493374 cites W2021667366 @default.
- W2071493374 cites W2022337217 @default.
- W2071493374 cites W2022737924 @default.
- W2071493374 cites W2024234652 @default.
- W2071493374 cites W2027753197 @default.
- W2071493374 cites W2030030872 @default.
- W2071493374 cites W2033058427 @default.
- W2071493374 cites W2037142040 @default.
- W2071493374 cites W2039992465 @default.
- W2071493374 cites W2040328785 @default.
- W2071493374 cites W2040753914 @default.
- W2071493374 cites W2046500896 @default.
- W2071493374 cites W2048411348 @default.
- W2071493374 cites W2051977733 @default.
- W2071493374 cites W2056016295 @default.
- W2071493374 cites W2061333499 @default.
- W2071493374 cites W2061713465 @default.
- W2071493374 cites W2064120191 @default.
- W2071493374 cites W2069510464 @default.
- W2071493374 cites W2070621900 @default.
- W2071493374 cites W2076975132 @default.
- W2071493374 cites W2084692792 @default.
- W2071493374 cites W2085397620 @default.
- W2071493374 cites W2100779832 @default.
- W2071493374 cites W2102192115 @default.
- W2071493374 cites W2102526743 @default.
- W2071493374 cites W2106643427 @default.
- W2071493374 cites W2112150914 @default.
- W2071493374 cites W2114519559 @default.
- W2071493374 cites W2117031630 @default.
- W2071493374 cites W2119331212 @default.
- W2071493374 cites W2124111649 @default.
- W2071493374 cites W2131751742 @default.
- W2071493374 cites W2133431562 @default.
- W2071493374 cites W2134018311 @default.
- W2071493374 cites W2134810803 @default.
- W2071493374 cites W2138900790 @default.
- W2071493374 cites W2145027792 @default.
- W2071493374 cites W2145142659 @default.
- W2071493374 cites W2147029239 @default.
- W2071493374 cites W2147907319 @default.
- W2071493374 cites W2159211602 @default.
- W2071493374 cites W2165882881 @default.
- W2071493374 cites W2167400574 @default.
- W2071493374 cites W2168050451 @default.
- W2071493374 cites W2414033814 @default.
- W2071493374 cites W31735925 @default.
- W2071493374 cites W2040968408 @default.
- W2071493374 doi "https://doi.org/10.1371/journal.pone.0090696" @default.
- W2071493374 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3946216" @default.
- W2071493374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24603718" @default.
- W2071493374 hasPublicationYear "2014" @default.
- W2071493374 type Work @default.
- W2071493374 sameAs 2071493374 @default.
- W2071493374 citedByCount "48" @default.
- W2071493374 countsByYear W20714933742014 @default.
- W2071493374 countsByYear W20714933742015 @default.
- W2071493374 countsByYear W20714933742016 @default.
- W2071493374 countsByYear W20714933742017 @default.
- W2071493374 countsByYear W20714933742018 @default.
- W2071493374 countsByYear W20714933742019 @default.
- W2071493374 countsByYear W20714933742020 @default.
- W2071493374 countsByYear W20714933742021 @default.
- W2071493374 countsByYear W20714933742022 @default.
- W2071493374 crossrefType "journal-article" @default.
- W2071493374 hasAuthorship W2071493374A5007218090 @default.
- W2071493374 hasAuthorship W2071493374A5014957436 @default.
- W2071493374 hasAuthorship W2071493374A5018715142 @default.
- W2071493374 hasAuthorship W2071493374A5026110940 @default.