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• W2071502308 abstract "Exercise increases while physical inactivity decrease mitochondrial content and oxidative capacity of skeletal muscles in vivo. It is unknown whether mitochondrial mass and substrate oxidation are related in non-contracting skeletal muscle. Mitochondrial mass, ATP, ADP, AMP, glucose and lipid oxidation (complete and incomplete) were determined in non-contracting myotubes established from 10 lean, 10 obese and 10 subjects with type 2 diabetes precultured under normophysiological conditions. ATP, ADP, AMP, mitochondrial mass and energy charge were not different between groups. In diabetic myotubes, basal glucose oxidation and incomplete lipid oxidation were significantly increased while complete lipid oxidation was lower. Mitochondrial mass was not correlated to glucose oxidation or incomplete lipid oxidation in human myotubes but inversely correlated to complete lipid oxidation. Thus within a stable energetic background, an increased mitochondrial mass in human myotubes was not positive correlated to an increased substrate oxidation as expected from skeletal muscles in vivo but surprisingly with a reduced complete lipid oxidation." @default.
• W2071502308 created "2016-06-24" @default.
• W2071502308 creator A5014886487 @default.
• W2071502308 date "2011-01-01" @default.
• W2071502308 modified "2023-09-27" @default.
• W2071502308 title "Mitochondrial mass is inversely correlated to complete lipid oxidation in human myotubes" @default.
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• W2071502308 doi "https://doi.org/10.1016/j.bbrc.2010.12.102" @default.
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