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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071503299> ?p ?o ?g. }

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• W2071503299 abstract "Interleukin-1 (IL-1) is a central molecule in inflammation and immune responses whose pleiotropic activities are mediated by the type I IL-1 receptor (IL-1RI). The IL-1RI alone on the cell surface is silent after binding of the ligand. We show that the recently identified IL-1RI accessory protein (IL-1RAcP) converts the silent into a fully functional IL-1RI complex. Although transfection of IL-1RAcP into IL-1RAcP-deficient EL4D6/76 cells did not alter the binding kinetics or dissociation constants of the 125I-labeled IL-1alpha/IL-1RI complex, a very early event, internalization of the activated receptor complex, and a late event, IL-1-stimulated IL-2 production, were successfully restored. Therefore, recruitment of IL-1RAcP is a critical early step in the signaling cascade mediated by the IL-1RI activation complex." @default.
• W2071503299 created "2016-06-24" @default.
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• W2071503299 date "1997-01-01" @default.
• W2071503299 modified "2023-10-01" @default.
• W2071503299 title "A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling" @default.
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• W2071503299 doi "https://doi.org/10.1002/eji.1830270139" @default.
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