FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071504057> ?p ?o ?g. }

• W2071504057 endingPage "1168" @default.
• W2071504057 startingPage "1161" @default.
• W2071504057 abstract "Two families with a germline Asp820Tyr mutation at exon 17 of the c-kit gene and multiple gastrointestinal stromal tumors (GISTs) have been reported. Recently, we generated a knock-in mouse model of the family, and mice with KIT-Asp818Tyr corresponding to human KIT-Asp820Tyr showed a cecal GIST-like tumor. In this report, we examined the in vivo effect of imatinib on tumor progression in knock-in mice. Imatinib of 100 microg/g body weight was administered to heterozygous (KIT-Asp818Tyr/+) mice orally for 7, 14 and 28 days, and cecal tumors were dissected. Both macroscopic size and the measured volume of cecal tumors were not significantly reduced after a 7-, 14- and 28-day administration of imatinib when compared with those before imatinib administration. Cell proliferation was assessed by Ki-67 immunohistochemistry and the labeling index significantly decreased after imatinib administration, but the value of the index after imatinib was only about half compared with that before imatinib. Western blotting and real-time PCR revealed that KIT expression was almost equivalent, but KIT phosphorylation was significantly but not completely inhibited in tumor tissues after 7, 14 and 28 days of imatinib administration when compared with that before imatinib administration. Phosphorylation of Akt and Stat1 was accordingly inhibited after imatinib administration. Thus, imatinib seemed to inhibit in vivo tumor proliferation but not decrease tumor volume on this mouse model, probably because of an insufficient inhibition of phosphorylation of KIT and its downstream signaling molecules. These results suggested that progression of multiple GISTs in patients with germline Asp820Tyr might be partially controlled by imatinib and that model mice provide an opportunity to examine the effect of various other targeted drugs on in vivo tumor progression." @default.
• W2071504057 created "2016-06-24" @default.
• W2071504057 creator A5000521371 @default.
• W2071504057 creator A5011226241 @default.
• W2071504057 creator A5015732550 @default.
• W2071504057 creator A5028737176 @default.
• W2071504057 creator A5037563122 @default.
• W2071504057 creator A5038090853 @default.
• W2071504057 creator A5068543044 @default.
• W2071504057 creator A5076928051 @default.
• W2071504057 creator A5081553751 @default.
• W2071504057 creator A5085701476 @default.
• W2071504057 creator A5087348287 @default.
• W2071504057 date "2009-10-01" @default.
• W2071504057 modified "2023-10-16" @default.
• W2071504057 title "In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice" @default.
• W2071504057 cites W1514031343 @default.
• W2071504057 cites W1549034776 @default.
• W2071504057 cites W1734860714 @default.
• W2071504057 cites W1752312133 @default.
• W2071504057 cites W1968775513 @default.
• W2071504057 cites W1970226788 @default.
• W2071504057 cites W1975240950 @default.
• W2071504057 cites W1976823322 @default.
• W2071504057 cites W1978095082 @default.
• W2071504057 cites W1991175004 @default.
• W2071504057 cites W1994834086 @default.
• W2071504057 cites W1995930366 @default.
• W2071504057 cites W1997103047 @default.
• W2071504057 cites W2000998080 @default.
• W2071504057 cites W2015015957 @default.
• W2071504057 cites W2016899343 @default.
• W2071504057 cites W2027636000 @default.
• W2071504057 cites W2035157342 @default.
• W2071504057 cites W2039037540 @default.
• W2071504057 cites W2044454561 @default.
• W2071504057 cites W2055763832 @default.
• W2071504057 cites W2062593881 @default.
• W2071504057 cites W2063436204 @default.
• W2071504057 cites W2080350750 @default.
• W2071504057 cites W2083330805 @default.
• W2071504057 cites W2103304755 @default.
• W2071504057 cites W2103322585 @default.
• W2071504057 cites W2103774582 @default.
• W2071504057 cites W2105396280 @default.
• W2071504057 cites W2107590922 @default.
• W2071504057 cites W2112811492 @default.
• W2071504057 cites W2113121713 @default.
• W2071504057 cites W2119151047 @default.
• W2071504057 cites W2119455657 @default.
• W2071504057 cites W2123571541 @default.
• W2071504057 cites W2126042521 @default.
• W2071504057 cites W2130755604 @default.
• W2071504057 cites W2133771964 @default.
• W2071504057 cites W2134094496 @default.
• W2071504057 cites W2137211135 @default.
• W2071504057 cites W2140922568 @default.
• W2071504057 cites W2149698450 @default.
• W2071504057 cites W2151900782 @default.
• W2071504057 cites W2159360580 @default.
• W2071504057 cites W2165720262 @default.
• W2071504057 cites W2171620774 @default.
• W2071504057 cites W2253046940 @default.
• W2071504057 cites W2325670521 @default.
• W2071504057 cites W2329648702 @default.
• W2071504057 cites W4246876375 @default.
• W2071504057 doi "https://doi.org/10.1038/labinvest.2009.78" @default.
• W2071504057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19636292" @default.
• W2071504057 hasPublicationYear "2009" @default.
• W2071504057 type Work @default.
• W2071504057 sameAs 2071504057 @default.
• W2071504057 citedByCount "5" @default.
• W2071504057 countsByYear W20715040572015 @default.
• W2071504057 countsByYear W20715040572017 @default.
• W2071504057 countsByYear W20715040572021 @default.
• W2071504057 crossrefType "journal-article" @default.
• W2071504057 hasAuthorship W2071504057A5000521371 @default.
• W2071504057 hasAuthorship W2071504057A5011226241 @default.
• W2071504057 hasAuthorship W2071504057A5015732550 @default.
• W2071504057 hasAuthorship W2071504057A5028737176 @default.
• W2071504057 hasAuthorship W2071504057A5037563122 @default.
• W2071504057 hasAuthorship W2071504057A5038090853 @default.
• W2071504057 hasAuthorship W2071504057A5068543044 @default.
• W2071504057 hasAuthorship W2071504057A5076928051 @default.
• W2071504057 hasAuthorship W2071504057A5081553751 @default.
• W2071504057 hasAuthorship W2071504057A5085701476 @default.
• W2071504057 hasAuthorship W2071504057A5087348287 @default.
• W2071504057 hasBestOaLocation W20715040571 @default.
• W2071504057 hasConcept C142724271 @default.
• W2071504057 hasConcept C150903083 @default.
• W2071504057 hasConcept C16930146 @default.
• W2071504057 hasConcept C207001950 @default.
• W2071504057 hasConcept C2775922572 @default.
• W2071504057 hasConcept C2777007597 @default.
• W2071504057 hasConcept C2777583451 @default.
• W2071504057 hasConcept C2778729363 @default.
• W2071504057 hasConcept C3019892230 @default.
• W2071504057 hasConcept C502942594 @default.

• next