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- W2071511983 abstract "Sphingomyelins (SMs) are important constituents of the plasma membrane and have, together with other sphingolipids and sterols, been identified as lipid components in membrane rafts. Interactions between sphingolipids and sterols have been shown to be important for the formation of ordered domains in model systems and also suggested to be a driving force in the formation of membrane rafts. The structure of sphingomyelins is important for interactions with sterols and in this study we have investigated the importance of the methyl groups in the head group of SMs upon membrane properties and interactions with cholesterol. Using specifically synthesized SM-analogues, having a stepwise decreasing number of methyl groups in the phosphocholine head group, we are able to systematically study how the size of the head group affects membrane properties and sterol interactions. The sphingomyelin analogues were composed of sphingosine having palmitic acid in the N-linked position. Using the anisotropy of 1,6-diphenylhexatriene we have determined the transition temperature between gel and liquid crystalline phases (Tm). Decreased methylation of the head group was shown to increase the Tm from 42°C (PSM), 53°C (dimethyl), 61°C (monomethyl) to 65 °C for ceramide-phoshoethanolamine (no methyl groups). Initial experiments using fluorescence quenching of cholestatrienol in complex model systems, shows that the ability to form sterol containing ordered domains also is affected by the degree of methylation in the head group. We are currently analyzing sterol interaction for the SM-analogues using DPH anisotropy and further prospects include determination sterol partitioning to vesicles containing each of the SM-analogues and differential scanning calorimetry studies." @default.
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- W2071511983 date "2010-01-01" @default.
- W2071511983 modified "2023-09-28" @default.
- W2071511983 title "Importance of Head Group Methylation on Sphingomyelin Membrane Properties and Interactions with Cholesterol" @default.
- W2071511983 doi "https://doi.org/10.1016/j.bpj.2009.12.2668" @default.
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