FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071517406> ?p ?o ?g. }

• W2071517406 endingPage "52" @default.
• W2071517406 startingPage "46" @default.
• W2071517406 abstract "Bacterial response regulators (RR) that function as transcription factors in two component signaling pathways are crucial for ensuring tight regulation and coordinated expression of the genome. Currently, consensus DNA binding sites in the promoter for very few bacterial RRs have been identified. A systematic method to characterize these DNA binding sites for RRs would enable prediction of specific gene expression patterns in response to extracellular stimuli. To identify RR DNA binding sites, we functionally activated RRs using beryllofluoride and applied them to a protein-binding microarray (PBM) to discover DNA binding motifs for RRs expressed in Burkholderia, a Gram-negative bacterial genus. We identified DNA binding motifs for conserved RRs in Burkholderia thailandensis, including KdpE, RisA, and NarL, as well as for a previously uncharacterized RR at locus BTH_II2335 and its ortholog in the human pathogen Burkholderia pseudomallei at locus BPSS2315. We further demonstrate RR binding of predicted genomic targets for the two orthologs using gel shift assays and reveal a pattern of RR regulation of expression of self and other two component systems. Our studies illustrate the use of PBMs to identify DNA binding specificities for bacterial RRs and enable prediction of gene regulatory networks in response to two component signaling." @default.
• W2071517406 created "2016-06-24" @default.
• W2071517406 creator A5022793929 @default.
• W2071517406 creator A5023810299 @default.
• W2071517406 creator A5040266829 @default.
• W2071517406 creator A5050869205 @default.
• W2071517406 creator A5064230419 @default.
• W2071517406 creator A5079124579 @default.
• W2071517406 date "2012-07-01" @default.
• W2071517406 modified "2023-09-22" @default.
• W2071517406 title "DNA binding site analysis of Burkholderia thailandensis response regulators" @default.
• W2071517406 cites W1593897888 @default.
• W2071517406 cites W1975036436 @default.
• W2071517406 cites W1985032743 @default.
• W2071517406 cites W1994122295 @default.
• W2071517406 cites W2002099745 @default.
• W2071517406 cites W2002386018 @default.
• W2071517406 cites W2008200635 @default.
• W2071517406 cites W2021582328 @default.
• W2071517406 cites W2039761675 @default.
• W2071517406 cites W2042392223 @default.
• W2071517406 cites W2046032824 @default.
• W2071517406 cites W2048205348 @default.
• W2071517406 cites W2054823707 @default.
• W2071517406 cites W2061637633 @default.
• W2071517406 cites W2061834804 @default.
• W2071517406 cites W2072481359 @default.
• W2071517406 cites W2073075400 @default.
• W2071517406 cites W2073978055 @default.
• W2071517406 cites W2078742086 @default.
• W2071517406 cites W2080152736 @default.
• W2071517406 cites W2092941764 @default.
• W2071517406 cites W2094002418 @default.
• W2071517406 cites W2095749144 @default.
• W2071517406 cites W2096926750 @default.
• W2071517406 cites W2097341137 @default.
• W2071517406 cites W2105419109 @default.
• W2071517406 cites W2109109270 @default.
• W2071517406 cites W2110899662 @default.
• W2071517406 cites W2115851903 @default.
• W2071517406 cites W2120109324 @default.
• W2071517406 cites W2120423879 @default.
• W2071517406 cites W2121919129 @default.
• W2071517406 cites W2139064328 @default.
• W2071517406 cites W2139347509 @default.
• W2071517406 cites W2147051160 @default.
• W2071517406 cites W2147390657 @default.
• W2071517406 cites W2154840766 @default.
• W2071517406 cites W2156627746 @default.
• W2071517406 cites W2156783635 @default.
• W2071517406 cites W2158500148 @default.
• W2071517406 cites W2165131069 @default.
• W2071517406 cites W2169636286 @default.
• W2071517406 doi "https://doi.org/10.1016/j.mimet.2012.03.019" @default.
• W2071517406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22521922" @default.
• W2071517406 hasPublicationYear "2012" @default.
• W2071517406 type Work @default.
• W2071517406 sameAs 2071517406 @default.
• W2071517406 citedByCount "5" @default.
• W2071517406 countsByYear W20715174062014 @default.
• W2071517406 countsByYear W20715174062018 @default.
• W2071517406 countsByYear W20715174062020 @default.
• W2071517406 countsByYear W20715174062021 @default.
• W2071517406 crossrefType "journal-article" @default.
• W2071517406 hasAuthorship W2071517406A5022793929 @default.
• W2071517406 hasAuthorship W2071517406A5023810299 @default.
• W2071517406 hasAuthorship W2071517406A5040266829 @default.
• W2071517406 hasAuthorship W2071517406A5050869205 @default.
• W2071517406 hasAuthorship W2071517406A5064230419 @default.
• W2071517406 hasAuthorship W2071517406A5079124579 @default.
• W2071517406 hasConcept C101762097 @default.
• W2071517406 hasConcept C104317684 @default.
• W2071517406 hasConcept C107824862 @default.
• W2071517406 hasConcept C143065580 @default.
• W2071517406 hasConcept C150194340 @default.
• W2071517406 hasConcept C165864922 @default.
• W2071517406 hasConcept C2779110727 @default.
• W2071517406 hasConcept C2780855054 @default.
• W2071517406 hasConcept C2781196521 @default.
• W2071517406 hasConcept C3662595 @default.
• W2071517406 hasConcept C523546767 @default.
• W2071517406 hasConcept C54355233 @default.
• W2071517406 hasConcept C552990157 @default.
• W2071517406 hasConcept C62361671 @default.
• W2071517406 hasConcept C70721500 @default.
• W2071517406 hasConcept C86339819 @default.
• W2071517406 hasConcept C86803240 @default.
• W2071517406 hasConceptScore W2071517406C101762097 @default.
• W2071517406 hasConceptScore W2071517406C104317684 @default.
• W2071517406 hasConceptScore W2071517406C107824862 @default.
• W2071517406 hasConceptScore W2071517406C143065580 @default.
• W2071517406 hasConceptScore W2071517406C150194340 @default.
• W2071517406 hasConceptScore W2071517406C165864922 @default.
• W2071517406 hasConceptScore W2071517406C2779110727 @default.
• W2071517406 hasConceptScore W2071517406C2780855054 @default.
• W2071517406 hasConceptScore W2071517406C2781196521 @default.
• W2071517406 hasConceptScore W2071517406C3662595 @default.
• W2071517406 hasConceptScore W2071517406C523546767 @default.

• next