Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071518066> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2071518066 endingPage "316" @default.
- W2071518066 startingPage "311" @default.
- W2071518066 abstract "Several studies have shown that the nervous (and hormonal) system controls immune functions. In the present study, we examined the presence of muscarinic acetylcholine receptors and the effect of carbachol on DNA fragmentation in adult rat thymocytes. Rat thymocytes possessed high affinity binding sites for the muscarinic antagonist [3H]3-quinuclidinyl benzilate (QNB). The average number of binding sites per cells was 3000, and the equilibrium dissociation constant of [3H]QNB on intact cell was approximately 80 nM. The binding was inhibited by an Ml- and M3-selective antagonist, 4-diphenylacetoxy-7V-methylpiperidine methiodine (4-DAMP). Hydrocortisone (100 mg/kg, s.c.) treatment of rats for 2 days prior to sacrifice increased the average number of [3H]QNB binding sites on thymocytes by 82 + 33%. The gel electrophoresis of DNA extracted from carbachol-treated thymocytes revealed a ladder pattern typical of intranucleosomal fragmentation. The addition of oxotremorine-M also induced DNA fragmentation and the effects of muscarinic agonists were inhibited by the addition of atropine or 4-DAMP. The results suggest the existence of muscarinic receptors and the possible involvement in apoptosis in thymocytes." @default.
- W2071518066 created "2016-06-24" @default.
- W2071518066 creator A5009113447 @default.
- W2071518066 creator A5023328943 @default.
- W2071518066 creator A5053697998 @default.
- W2071518066 date "1997-01-01" @default.
- W2071518066 modified "2023-09-30" @default.
- W2071518066 title "Muscarinic Acetylcholine Receptors on Rat Thymocytes: Their Possible Involvement in DNA Fragmentation" @default.
- W2071518066 cites W1559184092 @default.
- W2071518066 cites W1863559933 @default.
- W2071518066 cites W1923009678 @default.
- W2071518066 cites W1967201723 @default.
- W2071518066 cites W1971776926 @default.
- W2071518066 cites W1979877964 @default.
- W2071518066 cites W1987994348 @default.
- W2071518066 cites W2044358712 @default.
- W2071518066 cites W2049425355 @default.
- W2071518066 cites W2052244870 @default.
- W2071518066 cites W2058315273 @default.
- W2071518066 cites W2066926642 @default.
- W2071518066 cites W2080698860 @default.
- W2071518066 cites W2084609653 @default.
- W2071518066 cites W2237043109 @default.
- W2071518066 doi "https://doi.org/10.1254/jjp.60.311" @default.
- W2071518066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1491520" @default.
- W2071518066 hasPublicationYear "1997" @default.
- W2071518066 type Work @default.
- W2071518066 sameAs 2071518066 @default.
- W2071518066 citedByCount "19" @default.
- W2071518066 countsByYear W20715180662014 @default.
- W2071518066 countsByYear W20715180662016 @default.
- W2071518066 crossrefType "journal-article" @default.
- W2071518066 hasAuthorship W2071518066A5009113447 @default.
- W2071518066 hasAuthorship W2071518066A5023328943 @default.
- W2071518066 hasAuthorship W2071518066A5053697998 @default.
- W2071518066 hasBestOaLocation W20715180661 @default.
- W2071518066 hasConcept C126322002 @default.
- W2071518066 hasConcept C134018914 @default.
- W2071518066 hasConcept C153911025 @default.
- W2071518066 hasConcept C170493617 @default.
- W2071518066 hasConcept C185592680 @default.
- W2071518066 hasConcept C190283241 @default.
- W2071518066 hasConcept C24998067 @default.
- W2071518066 hasConcept C2775859210 @default.
- W2071518066 hasConcept C2776723954 @default.
- W2071518066 hasConcept C2776885963 @default.
- W2071518066 hasConcept C2778824757 @default.
- W2071518066 hasConcept C2778988552 @default.
- W2071518066 hasConcept C2908651707 @default.
- W2071518066 hasConcept C31573885 @default.
- W2071518066 hasConcept C33789571 @default.
- W2071518066 hasConcept C43759708 @default.
- W2071518066 hasConcept C55493867 @default.
- W2071518066 hasConcept C71924100 @default.
- W2071518066 hasConcept C86803240 @default.
- W2071518066 hasConceptScore W2071518066C126322002 @default.
- W2071518066 hasConceptScore W2071518066C134018914 @default.
- W2071518066 hasConceptScore W2071518066C153911025 @default.
- W2071518066 hasConceptScore W2071518066C170493617 @default.
- W2071518066 hasConceptScore W2071518066C185592680 @default.
- W2071518066 hasConceptScore W2071518066C190283241 @default.
- W2071518066 hasConceptScore W2071518066C24998067 @default.
- W2071518066 hasConceptScore W2071518066C2775859210 @default.
- W2071518066 hasConceptScore W2071518066C2776723954 @default.
- W2071518066 hasConceptScore W2071518066C2776885963 @default.
- W2071518066 hasConceptScore W2071518066C2778824757 @default.
- W2071518066 hasConceptScore W2071518066C2778988552 @default.
- W2071518066 hasConceptScore W2071518066C2908651707 @default.
- W2071518066 hasConceptScore W2071518066C31573885 @default.
- W2071518066 hasConceptScore W2071518066C33789571 @default.
- W2071518066 hasConceptScore W2071518066C43759708 @default.
- W2071518066 hasConceptScore W2071518066C55493867 @default.
- W2071518066 hasConceptScore W2071518066C71924100 @default.
- W2071518066 hasConceptScore W2071518066C86803240 @default.
- W2071518066 hasIssue "4" @default.
- W2071518066 hasLocation W20715180661 @default.
- W2071518066 hasLocation W20715180662 @default.
- W2071518066 hasOpenAccess W2071518066 @default.
- W2071518066 hasPrimaryLocation W20715180661 @default.
- W2071518066 hasRelatedWork W1970289512 @default.
- W2071518066 hasRelatedWork W1986292963 @default.
- W2071518066 hasRelatedWork W2015081541 @default.
- W2071518066 hasRelatedWork W2033279658 @default.
- W2071518066 hasRelatedWork W2071518066 @default.
- W2071518066 hasRelatedWork W2094813013 @default.
- W2071518066 hasRelatedWork W2166121774 @default.
- W2071518066 hasRelatedWork W2396468581 @default.
- W2071518066 hasRelatedWork W2402783545 @default.
- W2071518066 hasRelatedWork W2555438540 @default.
- W2071518066 hasVolume "73" @default.
- W2071518066 isParatext "false" @default.
- W2071518066 isRetracted "false" @default.
- W2071518066 magId "2071518066" @default.
- W2071518066 workType "article" @default.