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• W2071524459 abstract "It is well known that fibroblasts can act as a cell vector to express functional protein, like neurotrophin-4 (NT-4). The present study evaluated the effect of NT-4 gene modified fibroblasts grafted into the hippocampus of AD rat model. AD rats were reproduced by bilateral transection of the hippocampal fimbria-fornix. The transplanted fibroblasts steadily expressed NT-4 proteins at least 2 months after transplantation. This correlated with a significant rescue in the number of cholinergic neurons in the host hippocampus. Morris water maze tests demonstrated significant improvements in learning and memory, especially in rats receiving NT-4-modified fibroblasts. The present results showed that NT-4 gene modified fibroblasts could provide a long-term and steady expression of NT-4, and it significantly improved the behavior of AD rats. These findings should have important clinical applications in providing a long-term NT-4 Secretion for the treatment of AD." @default.
• W2071524459 created "2016-06-24" @default.
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• W2071524459 date "2009-11-01" @default.
• W2071524459 modified "2023-10-10" @default.
• W2071524459 title "Effects of NT-4 gene modified fibroblasts transplanted into AD rats" @default.
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• W2071524459 doi "https://doi.org/10.1016/j.neulet.2009.09.020" @default.
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