Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071527253> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2071527253 endingPage "125" @default.
- W2071527253 startingPage "125" @default.
- W2071527253 abstract "Viral diversity is a key problem for the design of effective and universal vaccines. Virtually, a vaccine candidate including most of the diversity for a given epitope would force the virus to create escape mutants above the viability threshold or with a high fitness cost. Therefore, I hypothesize that priming the immune system with polyvalent vaccines where each single vehicle generates and displays multiple antigen variants in vivo, will elicit a broad and long-lasting immune response able to avoid viral escape. To this purpose, I propose the use of yeasts that carry virus-like particles designed to pack the antigen-coding RNA inside and replicate it via RNA-dependent RNA polymerase. This would produce diversity in vivo limited to the target of interest and without killing the vaccine vehicle. This approach is in contrast with peptide cocktails synthesized in vitro and polyvalent strategies where every cell or vector displays a single or definite number of mutants; but similarly to all them, it should be able to overcome original antigenic sin, avoid major histocompatibility complex restriction, and elicit broad cross-reactive immune responses. Here I discuss additional advantages such as minimal global antagonism or those derived from using a yeast vehicle, and potential drawbacks like autoimmunity. Diversity generated by this method could be monitored both genotypically and phenotypically, and therefore selected or discarded before use if needed." @default.
- W2071527253 created "2016-06-24" @default.
- W2071527253 creator A5090813043 @default.
- W2071527253 date "2007-01-01" @default.
- W2071527253 modified "2023-10-16" @default.
- W2071527253 title "Overcoming viral escape with vaccines that generate and display antigen diversity in vivo" @default.
- W2071527253 cites W1546831560 @default.
- W2071527253 cites W1564078780 @default.
- W2071527253 cites W1593193715 @default.
- W2071527253 cites W1797827588 @default.
- W2071527253 cites W1837570225 @default.
- W2071527253 cites W1965917259 @default.
- W2071527253 cites W1970724070 @default.
- W2071527253 cites W1981512482 @default.
- W2071527253 cites W2006515154 @default.
- W2071527253 cites W2008268571 @default.
- W2071527253 cites W2015125044 @default.
- W2071527253 cites W2015396071 @default.
- W2071527253 cites W2017945314 @default.
- W2071527253 cites W2022017192 @default.
- W2071527253 cites W2036816190 @default.
- W2071527253 cites W2048499136 @default.
- W2071527253 cites W2057677010 @default.
- W2071527253 cites W2059613424 @default.
- W2071527253 cites W2070748268 @default.
- W2071527253 cites W2081398616 @default.
- W2071527253 cites W2093658347 @default.
- W2071527253 cites W2097594050 @default.
- W2071527253 cites W2120479348 @default.
- W2071527253 cites W2151285285 @default.
- W2071527253 cites W2155228203 @default.
- W2071527253 cites W2158448913 @default.
- W2071527253 cites W2163184777 @default.
- W2071527253 cites W2169392074 @default.
- W2071527253 doi "https://doi.org/10.1186/1743-422x-4-125" @default.
- W2071527253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169210" @default.
- W2071527253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18034902" @default.
- W2071527253 hasPublicationYear "2007" @default.
- W2071527253 type Work @default.
- W2071527253 sameAs 2071527253 @default.
- W2071527253 citedByCount "2" @default.
- W2071527253 countsByYear W20715272532017 @default.
- W2071527253 crossrefType "journal-article" @default.
- W2071527253 hasAuthorship W2071527253A5090813043 @default.
- W2071527253 hasBestOaLocation W20715272531 @default.
- W2071527253 hasConcept C100701293 @default.
- W2071527253 hasConcept C147483822 @default.
- W2071527253 hasConcept C159047783 @default.
- W2071527253 hasConcept C195616568 @default.
- W2071527253 hasConcept C203014093 @default.
- W2071527253 hasConcept C2522874641 @default.
- W2071527253 hasConcept C59822182 @default.
- W2071527253 hasConcept C70721500 @default.
- W2071527253 hasConcept C81444415 @default.
- W2071527253 hasConcept C86803240 @default.
- W2071527253 hasConcept C8891405 @default.
- W2071527253 hasConceptScore W2071527253C100701293 @default.
- W2071527253 hasConceptScore W2071527253C147483822 @default.
- W2071527253 hasConceptScore W2071527253C159047783 @default.
- W2071527253 hasConceptScore W2071527253C195616568 @default.
- W2071527253 hasConceptScore W2071527253C203014093 @default.
- W2071527253 hasConceptScore W2071527253C2522874641 @default.
- W2071527253 hasConceptScore W2071527253C59822182 @default.
- W2071527253 hasConceptScore W2071527253C70721500 @default.
- W2071527253 hasConceptScore W2071527253C81444415 @default.
- W2071527253 hasConceptScore W2071527253C86803240 @default.
- W2071527253 hasConceptScore W2071527253C8891405 @default.
- W2071527253 hasIssue "1" @default.
- W2071527253 hasLocation W20715272531 @default.
- W2071527253 hasLocation W20715272532 @default.
- W2071527253 hasLocation W20715272533 @default.
- W2071527253 hasLocation W20715272534 @default.
- W2071527253 hasOpenAccess W2071527253 @default.
- W2071527253 hasPrimaryLocation W20715272531 @default.
- W2071527253 hasRelatedWork W1979044599 @default.
- W2071527253 hasRelatedWork W2009867644 @default.
- W2071527253 hasRelatedWork W2021824670 @default.
- W2071527253 hasRelatedWork W2060253881 @default.
- W2071527253 hasRelatedWork W2075879923 @default.
- W2071527253 hasRelatedWork W2182598264 @default.
- W2071527253 hasRelatedWork W2363997565 @default.
- W2071527253 hasRelatedWork W2408448169 @default.
- W2071527253 hasRelatedWork W3036615648 @default.
- W2071527253 hasRelatedWork W1981120125 @default.
- W2071527253 hasVolume "4" @default.
- W2071527253 isParatext "false" @default.
- W2071527253 isRetracted "false" @default.
- W2071527253 magId "2071527253" @default.
- W2071527253 workType "article" @default.