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• W2071529815 abstract "Bikunin is a Kunitz-type protease inhibitor predominantly found in human amniotic fluid. In cancers, administration of bikunin may block tumor cell invasion by a direct inhibition of tumor cell-associated plasmin activity as well as by inhibiting urokinase-type plasminogen activator (uPA) expression at the gene and protein levels, possibly through suppression of CD44 dimerization and/or the MAP kinase signaling cascade. Treatment of cancer patients with bikunin may be beneficial in the adjuvant setting to delay the onset of metastasis development and/or in combination with cytotoxic agents to improve treatment efficacy in patients with advanced ovarian cancer." @default.
• W2071529815 created "2016-06-24" @default.
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• W2071529815 date "2003-01-15" @default.
• W2071529815 modified "2023-10-14" @default.
• W2071529815 title "The Protease Inhibitor Bikunin, a Novel Anti-Metastatic Agent" @default.
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• W2071529815 doi "https://doi.org/10.1515/bc.2003.083" @default.
• W2071529815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12817471" @default.
• W2071529815 hasPublicationYear "2003" @default.
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