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- W2071533189 abstract "Dr Karcioglu is correct in observing that our discussion on sebaceous gland carcinoma of the eyelid could have extended beyond clinical recognition and management, and included insights into pathogenesis and systemic associations. As Dr Karcioglu reminds us, immunosuppressed patients with human immunodeficiency virus infection are predisposed to develop eyelid sebaceous gland carcinoma at a relatively young age.1Yen M.T. Tse D.T. Sebaceous cell carcinoma of the eyelid and the human immunodeficiency virus.Ophthal Plast Reconstr Surg. 2000; 16: 206-210Crossref PubMed Scopus (30) Google Scholar In addition, families harboring inherited defects in DNA mismatch repair enzymes are predisposed to visceral malignancies and sebaceous skin lesions, including sebaceous gland carcinoma of the eyelid—an association known as Muir–Torre syndrome.2Curry M.L. Eng W. Lund K. et al.Muir-Torre syndrome role of the dermatopathologist in diagnosis.Am J Dermatopathol. 2004; 26: 217-221Crossref PubMed Scopus (28) Google Scholar It is reasonable to speculate that the continued study of these predisposing factors may yield greater insight into the genomic pathogenesis of sebaceous gland carcinoma and may, in the future, affect the clinical management of this important neoplasia. Shields et al’s article was a retrospective review focusing on the authors’ past experience in the clinical recognition and management of 60 cases, a substantial collection for this relatively uncommon tumor. Sebaceous Carcinoma of the EyelidsOphthalmologyVol. 112Issue 9PreviewI read with interest Shields et al’s article1 and Hornblass and Lauer’s editorial2 on sebaceous gland carcinoma (SGC) of the eyelid. Although both pieces provide a substantially comprehensive review of clinical and morphologic features of SGC, as well as its current management and prognosis, I did not see any reference to the incidence and behavioral changes of these tumors in immunosuppressed patients. Full-Text PDF" @default.
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- W2071533189 date "2005-09-01" @default.
- W2071533189 modified "2023-09-25" @default.
- W2071533189 title "Sebaceous Carcinoma of the Eyelids: Author reply" @default.
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- W2071533189 doi "https://doi.org/10.1016/j.ophtha.2005.04.002" @default.
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