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- W2071539573 abstract "The mesangial cell of the renal glomerulus is exposed to circulating toxic substances and is a target involved in the glomerular component of chronic occupational and environmental exposure to cadmium. We review evidence for the involvement of cadmium in mesangial cell pathology, including effects on cell signaling, oncogene expression, and cell death. Previously we have shown that cadmium can inhibit apoptosis initiated through both the extrinsic (death ligand receptor) and intrinsic (mitochondrial) pathways, whereas exposure of mesangial cells to 10 μM CdCl2 for 6 h initiates caspase-independent cell death through both apoptotic and apoptotic-like (annexin V positive, propidium iodide staining) mechanisms. Apoptotic death is dependent upon activation of Ca2+/calmodulin-dependent protein kinase II (CaMK-II). In the present study we show that low level exposure of mesangial cells to Cd2+ (0.5 μM) initiates cell survival signals including PI3 kinase/Akt signaling, also dependent on CaMK-II, that are eventually overcome resulting in caspase-dependent cell death. These studies underscore the roles of cell signaling in various modes of cell death, and in particular the central role of CaMK-II in cadmium toxicology of the mesangial cell." @default.
- W2071539573 created "2016-06-24" @default.
- W2071539573 creator A5041935017 @default.
- W2071539573 creator A5045437842 @default.
- W2071539573 creator A5060002817 @default.
- W2071539573 date "2009-08-01" @default.
- W2071539573 modified "2023-10-02" @default.
- W2071539573 title "Pleiotropic effects of cadmium in mesangial cells" @default.
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