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• W2071544304 abstract "The purpose of this study was to determine whether subjects with high serum thyrotropin (TSH) levels and low-normal serum thyroxine (T4) levels are euthyroid, as a result of the increased TSH stimulation of the thyroid, or hypothyroid. As a model to study this clinically important problem we analyzed serum cholesterol (Chol), triglyceride (Tg), TSH, T4, and triiodothyroxine (T3) before and 7, 10, and 12 weeks after sham operation (SO), hemithyroidectomy (Htx), and total thyroidectomy (Ttx) in 33 male Sprague—Dawley rats. By 7 weeks after Ttx serum TSH levels increased from 861 ± 84 to 9657 ± 644 ng/ml, T4 decreased from 3.7 ± 0.18 to 0.84 ± 14 ng/ml, and T3 decreased from 0.317 ± 0.026 to 0.217 ± 0.007 ng/ml (P < 0.001). Serum Chol increased from 69.6 to 112.5 mg/dl, whereas Tg decreased from 70.93 ± 3.56 to 50.54 ± 4.18 mg/dl (P < 0.01). After Htx serum TSH levels were higher than before operation and were higher than in the SO group (P < 0.05); serum T4 and T3 levels tended to be lower than before Htx and lower than in the SO group, but this decrease was only significant for both T4 and T3 10 weeks after operation (P < 0.05); serum Chol and Tg levels were the same in Htx and SO animals. Thus, after Ttx (1) serum T3 and T4 levels decrease, (2) serum TSH levels increase, (3) serum Chol levels increase, and (4) serum Tg levels decrease. After Htx (1) serum TSH levels increase, (2) serum T3 and T4 levels are low-normal or slightly low, (3) serum Chol and Tg levels are normal. It appears that increased TSH stimulation of the thyroid gland can maintain normal serum lipid levels in the presence of low-normal or slightly low thyroid hormone concentrations. Thus, animals with increased serum TSH levels and low-normal or slightly low thyroid hormone levels are either not hypothyroid or serum lipid levels are an insensitive indicator of hypothyroidism." @default.
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• W2071544304 date "1979-12-01" @default.
• W2071544304 modified "2023-09-27" @default.
• W2071544304 title "Thyroid function and lipid concentration after thyroidectomy in rats" @default.
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• W2071544304 doi "https://doi.org/10.1016/0022-4804(79)90157-4" @default.
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