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• W2071544384 abstract "Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles. During S phase, SAS-6 molecules are first recruited to the proximal lumen of the mother centriole, adopting a cartwheel-like organization through interactions with the luminal wall, rather than via their self-oligomerization activity. The removal or release of luminal SAS-6 requires Plk4 and the cartwheel protein STIL. Abolishing either the recruitment or the removal of luminal SAS-6 hinders SAS-6 (or centriole) assembly at the outside wall of mother centrioles. After duplication, the lumen of engaged mother centrioles becomes inaccessible to SAS-6, correlating with a block for reduplication. These results lead to a proposed model that centrioles may duplicate via a template-based process to preserve their geometry and copy number." @default.
• W2071544384 created "2016-06-24" @default.
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• W2071544384 date "2014-07-01" @default.
• W2071544384 modified "2023-10-13" @default.
• W2071544384 title "SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication" @default.
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• W2071544384 doi "https://doi.org/10.1016/j.devcel.2014.05.008" @default.
• W2071544384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4116473" @default.
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• W2071544384 hasPublicationYear "2014" @default.
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