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- W2071549124 abstract "Introduction: Both the total amount of drug deposited in the lungs (whole lung deposition) and the amount deposited in different lung regions (regional lung deposition) are potentially important factors that determine the safety and efficacy of inhaled drugs. Radionuclide imaging is well established for quantifying the whole lung deposition of inhaled drugs, but the assessment of regional lung deposition is less straightforward, because of the complex nature of the lung anatomy. Areas covered: This review describes the challenges and problems associated with quantifying regional lung deposition by the two-dimensional (2D) radionuclide imaging method of gamma scintigraphy, and by the three-dimensional (3D) radionuclide imaging methods of single-photon-emission computed tomography (SPECT) and positron-emission tomography (PET). The advantages and disadvantages of each method for assessing regional lung deposition are discussed. Expert opinion: Owing to its 2D nature, gamma scintigraphy provides limited information about regional lung deposition. SPECT provides regional lung deposition data in three dimensions, but usually involves a 99mTc radiolabel. PET enables the regional lung deposition of radiolabeled drug molecules to be quantified in three dimensions, but poses the greatest logistical and technical difficulties. Despite their more challenging nature, 3D imaging methods should be considered as an alternative to gamma scintigraphy whenever the determination of regional lung deposition of pharmaceutical aerosols is a major study objective." @default.
- W2071549124 created "2016-06-24" @default.
- W2071549124 creator A5039747154 @default.
- W2071549124 creator A5041918036 @default.
- W2071549124 date "2011-05-10" @default.
- W2071549124 modified "2023-10-17" @default.
- W2071549124 title "Challenges in assessing regional distribution of inhaled drug in the human lungs" @default.
- W2071549124 cites W129066762 @default.
- W2071549124 cites W1508938702 @default.
- W2071549124 cites W1519480055 @default.
- W2071549124 cites W1529317955 @default.
- W2071549124 cites W1750834932 @default.
- W2071549124 cites W1967641134 @default.
- W2071549124 cites W1968694225 @default.
- W2071549124 cites W1970799115 @default.
- W2071549124 cites W1971012964 @default.
- W2071549124 cites W1975337343 @default.
- W2071549124 cites W1986851079 @default.
- W2071549124 cites W1987867546 @default.
- W2071549124 cites W1994099037 @default.
- W2071549124 cites W1997451627 @default.
- W2071549124 cites W2000065014 @default.
- W2071549124 cites W2002382641 @default.
- W2071549124 cites W2002594100 @default.
- W2071549124 cites W2006514814 @default.
- W2071549124 cites W2006545949 @default.
- W2071549124 cites W2007183298 @default.
- W2071549124 cites W2009525249 @default.
- W2071549124 cites W2009947229 @default.
- W2071549124 cites W2011094224 @default.
- W2071549124 cites W2013978737 @default.
- W2071549124 cites W2019677635 @default.
- W2071549124 cites W2024865305 @default.
- W2071549124 cites W2025018153 @default.
- W2071549124 cites W2028099371 @default.
- W2071549124 cites W2029827621 @default.
- W2071549124 cites W2031131155 @default.
- W2071549124 cites W2037625381 @default.
- W2071549124 cites W2043127169 @default.
- W2071549124 cites W2047755217 @default.
- W2071549124 cites W2050800340 @default.
- W2071549124 cites W2063226103 @default.
- W2071549124 cites W2067766634 @default.
- W2071549124 cites W2068758737 @default.
- W2071549124 cites W2069811863 @default.
- W2071549124 cites W2072144120 @default.
- W2071549124 cites W2074439263 @default.
- W2071549124 cites W2083839864 @default.
- W2071549124 cites W2084405887 @default.
- W2071549124 cites W2086460110 @default.
- W2071549124 cites W2089945128 @default.
- W2071549124 cites W2092641633 @default.
- W2071549124 cites W2095545535 @default.
- W2071549124 cites W2099526396 @default.
- W2071549124 cites W2104086406 @default.
- W2071549124 cites W2107742493 @default.
- W2071549124 cites W2109281756 @default.
- W2071549124 cites W2110305797 @default.
- W2071549124 cites W2111957786 @default.
- W2071549124 cites W2119045482 @default.
- W2071549124 cites W2120669622 @default.
- W2071549124 cites W2121073676 @default.
- W2071549124 cites W2129055319 @default.
- W2071549124 cites W2137324170 @default.
- W2071549124 cites W2148219802 @default.
- W2071549124 cites W2148252700 @default.
- W2071549124 cites W2151920893 @default.
- W2071549124 cites W2152312926 @default.
- W2071549124 cites W2155345300 @default.
- W2071549124 cites W2156315355 @default.
- W2071549124 cites W2163490535 @default.
- W2071549124 cites W2164193868 @default.
- W2071549124 cites W2170368758 @default.
- W2071549124 cites W2172822148 @default.
- W2071549124 cites W2177451823 @default.
- W2071549124 cites W2308595026 @default.
- W2071549124 cites W2326289599 @default.
- W2071549124 cites W2413124100 @default.
- W2071549124 cites W2598193067 @default.
- W2071549124 cites W4213189266 @default.
- W2071549124 cites W4232111640 @default.
- W2071549124 cites W4247991722 @default.
- W2071549124 cites W4255418524 @default.
- W2071549124 doi "https://doi.org/10.1517/17425247.2011.577063" @default.
- W2071549124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21554149" @default.
- W2071549124 hasPublicationYear "2011" @default.
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