Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071552617> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2071552617 endingPage "124" @default.
- W2071552617 startingPage "122" @default.
- W2071552617 abstract "<h2>Abstract</h2> Monoclonal antibodies to poliovirus type 3 secreted by nine mouse hybridoma cell lines were tested for virus-strain specificity with a collection of wild and vaccine-like type 3 viruses, the genetic characteristics of which had been determined by T1-oligonucleotide mapping. Four of the monoclonal antibodies had both virus-neutralising and antigen-blocking activity, and five had antigen-blocking activity only. Of the four virus-neutralising antibodies, two (NIBp138, NIBp165) reacted only with Sabin vaccine virus and other poliovirus type 3 strains with Sabin-like T1-oligonucleotide maps. Two antibodies (NIBp132, NIBp134) neutralised a broad range of type 3 viruses. Of five monoclonal antibodies with antigen-blocking activity only, four (NIBp135, NIBp136, NIBp140, and NIBp141) reacted exclusively with Sabin virus and strains with Sabin-like maps, and one (NIBp139) reacted with all type 3 strains tested. The vaccine-specific monoclonal antibodies, particularly NIBp138 and NIBp165, have considerable potential value in distinguishing wild type 3 viruses from those of Sabin vaccine origin. This conclusion was strongly supported by the finding that certain viruses which showed genetic evidence of being related to Sabin virus reacted well with vaccine-specific monoclonal antibodies despite having undergone genetic drift away from vaccine virus as indicated by changes in up to 30% of their oligonucleotides." @default.
- W2071552617 created "2016-06-24" @default.
- W2071552617 creator A5004014563 @default.
- W2071552617 creator A5038248074 @default.
- W2071552617 creator A5049352357 @default.
- W2071552617 creator A5055959254 @default.
- W2071552617 creator A5069099457 @default.
- W2071552617 creator A5073269960 @default.
- W2071552617 date "1982-07-01" @default.
- W2071552617 modified "2023-10-17" @default.
- W2071552617 title "MONOCLONAL ANTIBODIES SPECIFIC FOR THE SABIN VACCINE STRAIN OF POLIOVIRUS 3" @default.
- W2071552617 cites W1583790259 @default.
- W2071552617 cites W1965377951 @default.
- W2071552617 cites W1993947912 @default.
- W2071552617 cites W2004670971 @default.
- W2071552617 cites W2026638571 @default.
- W2071552617 cites W2030522563 @default.
- W2071552617 cites W2030583381 @default.
- W2071552617 cites W2040724436 @default.
- W2071552617 cites W2041578595 @default.
- W2071552617 cites W2095041881 @default.
- W2071552617 cites W2146032755 @default.
- W2071552617 cites W4248730030 @default.
- W2071552617 doi "https://doi.org/10.1016/s0140-6736(82)91091-1" @default.
- W2071552617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6123838" @default.
- W2071552617 hasPublicationYear "1982" @default.
- W2071552617 type Work @default.
- W2071552617 sameAs 2071552617 @default.
- W2071552617 citedByCount "41" @default.
- W2071552617 countsByYear W20715526172012 @default.
- W2071552617 countsByYear W20715526172014 @default.
- W2071552617 crossrefType "journal-article" @default.
- W2071552617 hasAuthorship W2071552617A5004014563 @default.
- W2071552617 hasAuthorship W2071552617A5038248074 @default.
- W2071552617 hasAuthorship W2071552617A5049352357 @default.
- W2071552617 hasAuthorship W2071552617A5055959254 @default.
- W2071552617 hasAuthorship W2071552617A5069099457 @default.
- W2071552617 hasAuthorship W2071552617A5073269960 @default.
- W2071552617 hasConcept C104317684 @default.
- W2071552617 hasConcept C129312508 @default.
- W2071552617 hasConcept C147483822 @default.
- W2071552617 hasConcept C159047783 @default.
- W2071552617 hasConcept C159654299 @default.
- W2071552617 hasConcept C203014093 @default.
- W2071552617 hasConcept C2522874641 @default.
- W2071552617 hasConcept C2779631682 @default.
- W2071552617 hasConcept C542903549 @default.
- W2071552617 hasConcept C54355233 @default.
- W2071552617 hasConcept C86803240 @default.
- W2071552617 hasConceptScore W2071552617C104317684 @default.
- W2071552617 hasConceptScore W2071552617C129312508 @default.
- W2071552617 hasConceptScore W2071552617C147483822 @default.
- W2071552617 hasConceptScore W2071552617C159047783 @default.
- W2071552617 hasConceptScore W2071552617C159654299 @default.
- W2071552617 hasConceptScore W2071552617C203014093 @default.
- W2071552617 hasConceptScore W2071552617C2522874641 @default.
- W2071552617 hasConceptScore W2071552617C2779631682 @default.
- W2071552617 hasConceptScore W2071552617C542903549 @default.
- W2071552617 hasConceptScore W2071552617C54355233 @default.
- W2071552617 hasConceptScore W2071552617C86803240 @default.
- W2071552617 hasIssue "8290" @default.
- W2071552617 hasLocation W20715526171 @default.
- W2071552617 hasLocation W20715526172 @default.
- W2071552617 hasOpenAccess W2071552617 @default.
- W2071552617 hasPrimaryLocation W20715526171 @default.
- W2071552617 hasRelatedWork W1487857142 @default.
- W2071552617 hasRelatedWork W1968866496 @default.
- W2071552617 hasRelatedWork W2010074320 @default.
- W2071552617 hasRelatedWork W2064089409 @default.
- W2071552617 hasRelatedWork W2070598222 @default.
- W2071552617 hasRelatedWork W2076922394 @default.
- W2071552617 hasRelatedWork W2098556738 @default.
- W2071552617 hasRelatedWork W2129272334 @default.
- W2071552617 hasRelatedWork W2401388660 @default.
- W2071552617 hasRelatedWork W2418298092 @default.
- W2071552617 hasVolume "320" @default.
- W2071552617 isParatext "false" @default.
- W2071552617 isRetracted "false" @default.
- W2071552617 magId "2071552617" @default.
- W2071552617 workType "article" @default.