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- W2071553378 abstract "The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-14C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on delta 5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on delta 5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP." @default.
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- W2071553378 date "1980-12-01" @default.
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- W2071553378 title "Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes" @default.
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- W2071553378 doi "https://doi.org/10.1007/bf02534325" @default.
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