Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071557324> ?p ?o ?g. }
- W2071557324 endingPage "1781" @default.
- W2071557324 startingPage "1771" @default.
- W2071557324 abstract "Grb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members, neuregulin-1beta (NRG-1beta, a paracrine factor produced from endothelium) induced remarkable tyrosine phosphorylation of Gab1 and Gab2 via erythroblastic leukemia viral oncogene (ErbB) receptors. We examined the role of Gab family proteins in NRG-1beta/ErbB-mediated signal in the heart by creating cardiomyocyte-specific Gab1/Gab2 double knockout mice (DKO mice). Although DKO mice were viable, they exhibited marked ventricular dilatation and reduced contractility with aging. DKO mice showed high mortality after birth because of heart failure. In addition, we noticed remarkable endocardial fibroelastosis and increase of abnormally dilated vessels in the ventricles of DKO mice. NRG-1beta induced activation of both ERK and AKT in the hearts of control mice but not in those of DKO mice. Using DNA microarray analysis, we found that stimulation with NRG-1beta upregulated expression of an endothelium-stabilizing factor, angiopoietin 1, in the hearts of control mice but not in those of DKO mice, which accounted for the pathological abnormalities in the DKO hearts. Taken together, our observations indicated that in the NRG-1beta/ErbB signaling, Gab1 and Gab2 of the myocardium are essential for both maintenance of myocardial function and stabilization of cardiac capillary and endocardial endothelium in the postnatal heart." @default.
- W2071557324 created "2016-06-24" @default.
- W2071557324 creator A5001645818 @default.
- W2071557324 creator A5012540837 @default.
- W2071557324 creator A5013187300 @default.
- W2071557324 creator A5014010927 @default.
- W2071557324 creator A5014423509 @default.
- W2071557324 creator A5022740787 @default.
- W2071557324 creator A5024625382 @default.
- W2071557324 creator A5025718888 @default.
- W2071557324 creator A5031015201 @default.
- W2071557324 creator A5037041497 @default.
- W2071557324 creator A5056051274 @default.
- W2071557324 creator A5056681640 @default.
- W2071557324 creator A5061682089 @default.
- W2071557324 creator A5068637876 @default.
- W2071557324 creator A5075054100 @default.
- W2071557324 creator A5076215096 @default.
- W2071557324 creator A5079504532 @default.
- W2071557324 creator A5080884513 @default.
- W2071557324 creator A5083348278 @default.
- W2071557324 date "2007-07-02" @default.
- W2071557324 modified "2023-10-16" @default.
- W2071557324 title "Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling" @default.
- W2071557324 cites W1654498070 @default.
- W2071557324 cites W1914550558 @default.
- W2071557324 cites W1963690717 @default.
- W2071557324 cites W1967628621 @default.
- W2071557324 cites W1967922846 @default.
- W2071557324 cites W1969707555 @default.
- W2071557324 cites W1970614272 @default.
- W2071557324 cites W1973415230 @default.
- W2071557324 cites W1978030865 @default.
- W2071557324 cites W1980141913 @default.
- W2071557324 cites W1982210988 @default.
- W2071557324 cites W1983530651 @default.
- W2071557324 cites W1991888662 @default.
- W2071557324 cites W1996430165 @default.
- W2071557324 cites W1997391548 @default.
- W2071557324 cites W2002806885 @default.
- W2071557324 cites W2014716406 @default.
- W2071557324 cites W2016010426 @default.
- W2071557324 cites W2017141883 @default.
- W2071557324 cites W2025128018 @default.
- W2071557324 cites W2026182775 @default.
- W2071557324 cites W2027264255 @default.
- W2071557324 cites W2030893402 @default.
- W2071557324 cites W2041474575 @default.
- W2071557324 cites W2043345702 @default.
- W2071557324 cites W2046971992 @default.
- W2071557324 cites W2050674912 @default.
- W2071557324 cites W2052110444 @default.
- W2071557324 cites W2064372096 @default.
- W2071557324 cites W2066048575 @default.
- W2071557324 cites W2066888615 @default.
- W2071557324 cites W2085939705 @default.
- W2071557324 cites W2088478532 @default.
- W2071557324 cites W2094864993 @default.
- W2071557324 cites W2098217994 @default.
- W2071557324 cites W2131929080 @default.
- W2071557324 cites W2134233137 @default.
- W2071557324 cites W2136860804 @default.
- W2071557324 cites W2139685274 @default.
- W2071557324 cites W2142826108 @default.
- W2071557324 cites W2143948360 @default.
- W2071557324 cites W2144593443 @default.
- W2071557324 cites W2145570802 @default.
- W2071557324 cites W2150588063 @default.
- W2071557324 cites W2152501837 @default.
- W2071557324 cites W2158257428 @default.
- W2071557324 cites W2158439676 @default.
- W2071557324 cites W2162014238 @default.
- W2071557324 cites W2164735544 @default.
- W2071557324 cites W2169503869 @default.
- W2071557324 cites W2171952998 @default.
- W2071557324 cites W2318605753 @default.
- W2071557324 cites W2416228519 @default.
- W2071557324 cites W4245030312 @default.
- W2071557324 doi "https://doi.org/10.1172/jci30651" @default.
- W2071557324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1888569" @default.
- W2071557324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17571162" @default.
- W2071557324 hasPublicationYear "2007" @default.
- W2071557324 type Work @default.
- W2071557324 sameAs 2071557324 @default.
- W2071557324 citedByCount "62" @default.
- W2071557324 countsByYear W20715573242012 @default.
- W2071557324 countsByYear W20715573242013 @default.
- W2071557324 countsByYear W20715573242014 @default.
- W2071557324 countsByYear W20715573242015 @default.
- W2071557324 countsByYear W20715573242016 @default.
- W2071557324 countsByYear W20715573242017 @default.
- W2071557324 countsByYear W20715573242018 @default.
- W2071557324 countsByYear W20715573242020 @default.
- W2071557324 countsByYear W20715573242021 @default.
- W2071557324 countsByYear W20715573242022 @default.
- W2071557324 crossrefType "journal-article" @default.
- W2071557324 hasAuthorship W2071557324A5001645818 @default.
- W2071557324 hasAuthorship W2071557324A5012540837 @default.