Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071563896> ?p ?o ?g. }
- W2071563896 abstract "There is a body of evidence that shows a link between tumorigenesis and ribosome biogenesis. The precursor of mature 18S, 28S and 5.8S ribosomal RNAs is transcribed from the ribosomal DNA gene (rDNA), which exists as 300–400 copies in the human diploid genome. Approximately one half of these copies are epigenetically silenced, but the exact role of epigenetic regulation on ribosome biogenesis is not completely understood. In this study we analyzed the methylation profiles of the rDNA promoter and of the 5’ regions of 18S and 28S in breast cancer. We analyzed rDNA methylation in 68 breast cancer tissues of which the normal counterpart was partially available (45/68 samples) using the MassARRAY EpiTYPER assay, a sensitive and quantitative method with single base resolution. We found that rDNA locus tended to be hypermethylated in tumor compared to matched normal breast tissues and that the DNA methylation level of several CpG units within the rDNA locus was associated to nuclear grade and to nucleolar size of tumor tissues. In addition we identified a subgroup of samples in which large nucleoli were associated with very limited or absent rDNA hypermethylation in tumor respect to matched normal tissue. In conclusion, we suggest that rDNA is an important target of epigenetic regulation in breast tumors and that rDNA methylation level is associated to nucleolar size." @default.
- W2071563896 created "2016-06-24" @default.
- W2071563896 creator A5003787691 @default.
- W2071563896 creator A5014652532 @default.
- W2071563896 creator A5021169959 @default.
- W2071563896 creator A5025931713 @default.
- W2071563896 creator A5034541363 @default.
- W2071563896 creator A5047717543 @default.
- W2071563896 creator A5065223581 @default.
- W2071563896 creator A5067507407 @default.
- W2071563896 creator A5070607006 @default.
- W2071563896 creator A5078302741 @default.
- W2071563896 date "2014-05-22" @default.
- W2071563896 modified "2023-10-18" @default.
- W2071563896 title "The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas" @default.
- W2071563896 cites W1558485979 @default.
- W2071563896 cites W1603913946 @default.
- W2071563896 cites W1964232579 @default.
- W2071563896 cites W1968419285 @default.
- W2071563896 cites W1980326316 @default.
- W2071563896 cites W1984121949 @default.
- W2071563896 cites W1994601218 @default.
- W2071563896 cites W2013045624 @default.
- W2071563896 cites W2014598834 @default.
- W2071563896 cites W2016323760 @default.
- W2071563896 cites W2016855149 @default.
- W2071563896 cites W2020828093 @default.
- W2071563896 cites W2027047074 @default.
- W2071563896 cites W2028094903 @default.
- W2071563896 cites W2028205719 @default.
- W2071563896 cites W2033693329 @default.
- W2071563896 cites W2037235549 @default.
- W2071563896 cites W2038169765 @default.
- W2071563896 cites W2043376848 @default.
- W2071563896 cites W2056839436 @default.
- W2071563896 cites W2062060771 @default.
- W2071563896 cites W2062993008 @default.
- W2071563896 cites W2063627542 @default.
- W2071563896 cites W2063969996 @default.
- W2071563896 cites W2064135927 @default.
- W2071563896 cites W2064583736 @default.
- W2071563896 cites W2076467621 @default.
- W2071563896 cites W2080213688 @default.
- W2071563896 cites W2082225623 @default.
- W2071563896 cites W2085439839 @default.
- W2071563896 cites W2088220740 @default.
- W2071563896 cites W2100893053 @default.
- W2071563896 cites W2109313324 @default.
- W2071563896 cites W2112426836 @default.
- W2071563896 cites W2123282517 @default.
- W2071563896 cites W2125234802 @default.
- W2071563896 cites W2126731001 @default.
- W2071563896 cites W2129104457 @default.
- W2071563896 cites W2131823236 @default.
- W2071563896 cites W2134985597 @default.
- W2071563896 cites W2150241164 @default.
- W2071563896 cites W2150727595 @default.
- W2071563896 cites W2151528379 @default.
- W2071563896 cites W2156874253 @default.
- W2071563896 cites W2158166500 @default.
- W2071563896 cites W2164142452 @default.
- W2071563896 cites W2885999730 @default.
- W2071563896 doi "https://doi.org/10.1186/1471-2407-14-361" @default.
- W2071563896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4062283" @default.
- W2071563896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24884608" @default.
- W2071563896 hasPublicationYear "2014" @default.
- W2071563896 type Work @default.
- W2071563896 sameAs 2071563896 @default.
- W2071563896 citedByCount "22" @default.
- W2071563896 countsByYear W20715638962015 @default.
- W2071563896 countsByYear W20715638962016 @default.
- W2071563896 countsByYear W20715638962017 @default.
- W2071563896 countsByYear W20715638962018 @default.
- W2071563896 countsByYear W20715638962019 @default.
- W2071563896 countsByYear W20715638962020 @default.
- W2071563896 countsByYear W20715638962022 @default.
- W2071563896 countsByYear W20715638962023 @default.
- W2071563896 crossrefType "journal-article" @default.
- W2071563896 hasAuthorship W2071563896A5003787691 @default.
- W2071563896 hasAuthorship W2071563896A5014652532 @default.
- W2071563896 hasAuthorship W2071563896A5021169959 @default.
- W2071563896 hasAuthorship W2071563896A5025931713 @default.
- W2071563896 hasAuthorship W2071563896A5034541363 @default.
- W2071563896 hasAuthorship W2071563896A5047717543 @default.
- W2071563896 hasAuthorship W2071563896A5065223581 @default.
- W2071563896 hasAuthorship W2071563896A5067507407 @default.
- W2071563896 hasAuthorship W2071563896A5070607006 @default.
- W2071563896 hasAuthorship W2071563896A5078302741 @default.
- W2071563896 hasBestOaLocation W20715638961 @default.
- W2071563896 hasConcept C104317684 @default.
- W2071563896 hasConcept C150194340 @default.
- W2071563896 hasConcept C153911025 @default.
- W2071563896 hasConcept C183873130 @default.
- W2071563896 hasConcept C189235521 @default.
- W2071563896 hasConcept C190062978 @default.
- W2071563896 hasConcept C190727270 @default.
- W2071563896 hasConcept C207812311 @default.
- W2071563896 hasConcept C2779419633 @default.
- W2071563896 hasConcept C33288867 @default.
- W2071563896 hasConcept C41091548 @default.