Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071567450> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2071567450 endingPage "1" @default.
- W2071567450 startingPage "1" @default.
- W2071567450 abstract "Open access liquid chromatography/tandem mass spectrometry: implementation of a fully quantitative system in a drug discovery laboratory John G Swales, Gary Wilkinson, Richard Gallagher, Clare Hammond, Charles O’Donnell, Raimund PeterAstraZeneca, Discovery Drug Metabolism and Pharmacokinetics, CVGI Research Area, Alderley Park, Macclesfield, Cheshire, UKAbstract: High performance liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) has been utilized to produce fully open access (OA) quantitative systems. The systems described have the ability to optimize the mass spectrometer analysis method, stack these optimizations, create the mass spectrometry analytical methods and automatically process data for reporting. An in-house, Microsoft® Excel-based sample list generator in conjunction with two manufacturers’ OA software packages have been implemented and are used exclusively for all in vivo and in vitro drug metabolism and pharmacokinetic assays within the department. We demonstrate that the OA systems have had a positive effect on the average turnaround times of all assays by utilizing the mass spectrometer time more effectively and by minimizing instrument downtime. Turnaround times have been monitored for 17 months post implementation of the OA systems as part of a Lean Six Sigma efficiency optimization project, and data are presented that support a sustained improvement throughout this period.Keywords: open access, DMPK, quantitation, bioanalysis, discovery" @default.
- W2071567450 created "2016-06-24" @default.
- W2071567450 creator A5004496008 @default.
- W2071567450 creator A5030379566 @default.
- W2071567450 creator A5045987787 @default.
- W2071567450 creator A5064572702 @default.
- W2071567450 creator A5072999145 @default.
- W2071567450 creator A5091435798 @default.
- W2071567450 date "2010-02-01" @default.
- W2071567450 modified "2023-09-26" @default.
- W2071567450 title "Open access liquid chromatography/tandem mass spectrometry: implementation of a fully quantitative system in a drug discovery laboratory" @default.
- W2071567450 doi "https://doi.org/10.2147/ijhts.s9061" @default.
- W2071567450 hasPublicationYear "2010" @default.
- W2071567450 type Work @default.
- W2071567450 sameAs 2071567450 @default.
- W2071567450 citedByCount "9" @default.
- W2071567450 countsByYear W20715674502012 @default.
- W2071567450 countsByYear W20715674502013 @default.
- W2071567450 countsByYear W20715674502014 @default.
- W2071567450 countsByYear W20715674502015 @default.
- W2071567450 countsByYear W20715674502016 @default.
- W2071567450 countsByYear W20715674502018 @default.
- W2071567450 countsByYear W20715674502019 @default.
- W2071567450 crossrefType "journal-article" @default.
- W2071567450 hasAuthorship W2071567450A5004496008 @default.
- W2071567450 hasAuthorship W2071567450A5030379566 @default.
- W2071567450 hasAuthorship W2071567450A5045987787 @default.
- W2071567450 hasAuthorship W2071567450A5064572702 @default.
- W2071567450 hasAuthorship W2071567450A5072999145 @default.
- W2071567450 hasAuthorship W2071567450A5091435798 @default.
- W2071567450 hasBestOaLocation W20715674501 @default.
- W2071567450 hasConcept C111919701 @default.
- W2071567450 hasConcept C137535248 @default.
- W2071567450 hasConcept C162356407 @default.
- W2071567450 hasConcept C176553487 @default.
- W2071567450 hasConcept C185592680 @default.
- W2071567450 hasConcept C31827203 @default.
- W2071567450 hasConcept C41008148 @default.
- W2071567450 hasConcept C43617362 @default.
- W2071567450 hasConcept C64489805 @default.
- W2071567450 hasConceptScore W2071567450C111919701 @default.
- W2071567450 hasConceptScore W2071567450C137535248 @default.
- W2071567450 hasConceptScore W2071567450C162356407 @default.
- W2071567450 hasConceptScore W2071567450C176553487 @default.
- W2071567450 hasConceptScore W2071567450C185592680 @default.
- W2071567450 hasConceptScore W2071567450C31827203 @default.
- W2071567450 hasConceptScore W2071567450C41008148 @default.
- W2071567450 hasConceptScore W2071567450C43617362 @default.
- W2071567450 hasConceptScore W2071567450C64489805 @default.
- W2071567450 hasLocation W20715674501 @default.
- W2071567450 hasOpenAccess W2071567450 @default.
- W2071567450 hasPrimaryLocation W20715674501 @default.
- W2071567450 hasRelatedWork W1840357638 @default.
- W2071567450 hasRelatedWork W1975023487 @default.
- W2071567450 hasRelatedWork W1976025442 @default.
- W2071567450 hasRelatedWork W2009697690 @default.
- W2071567450 hasRelatedWork W2015481396 @default.
- W2071567450 hasRelatedWork W2787820172 @default.
- W2071567450 hasRelatedWork W3017472692 @default.
- W2071567450 hasRelatedWork W3023432142 @default.
- W2071567450 hasRelatedWork W3028635380 @default.
- W2071567450 hasRelatedWork W3188441070 @default.
- W2071567450 isParatext "false" @default.
- W2071567450 isRetracted "false" @default.
- W2071567450 magId "2071567450" @default.
- W2071567450 workType "article" @default.