FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071569295> ?p ?o ?g. }

• W2071569295 abstract "Abstract Background It is currently unclear whether a correlation exists between N-myc downstream-regulated gene 2 (NDRG2) expression and oesophageal squamous cell carcinoma (ESCC). The aim of this study was to examine the underlying clinical significance of NDRG2 expression in ESCC patients and to investigate the effects of NDRG2 up-regulation on ESCC cell growth in vitro and in vivo. Methods Immunohistochemistry was used to determine the level of NDRG2 expressions in ESCC tissue, which was then compared to specific clinicopathological features in the patient and tissue specimens. Factors associated with patient survival were analysed. Moreover, the effects of up-regulating NDRG2 expression on the growth of an ESCC cell line were examined by MTT, colony formation, DNA replication activity and nude mouse model assays. Results Notably low expression of NDRG2 in ESCC patients was inversely associated with clinical stage, NM classification, histological differentiation and patients’ vital status (all P < 0.05). ESCC patients expressing high levels of NDRG2 exhibited a substantially higher 5-year overall survival rate than NDRG2-negative patients. Furthermore, NDRG2 over-expression reduced the proliferation, colony formation and DNA replication activity in ESCC cells, as well as inhibiting the growth of ESCC cells in vivo . Conclusion The present experiments demonstrated that NDRG2 may be a diagnostic and prognostic marker in patients with ESCC, and up-regulation of NDRG2 might act as a promising therapeutic strategy for aggressive ESCC." @default.
• W2071569295 created "2016-06-24" @default.
• W2071569295 creator A5005836955 @default.
• W2071569295 creator A5009600521 @default.
• W2071569295 creator A5073143460 @default.
• W2071569295 creator A5076185144 @default.
• W2071569295 date "2013-06-24" @default.
• W2071569295 modified "2023-10-15" @default.
• W2071569295 title "Low expression of N-myc downstream-regulated gene 2 in oesophageal squamous cell carcinoma correlates with a poor prognosis" @default.
• W2071569295 cites W1566527570 @default.
• W2071569295 cites W1573232677 @default.
• W2071569295 cites W1706217827 @default.
• W2071569295 cites W1963622707 @default.
• W2071569295 cites W1989413208 @default.
• W2071569295 cites W2001948277 @default.
• W2071569295 cites W2012027929 @default.
• W2071569295 cites W2045299298 @default.
• W2071569295 cites W2046887163 @default.
• W2071569295 cites W2050837935 @default.
• W2071569295 cites W2057234268 @default.
• W2071569295 cites W2079677014 @default.
• W2071569295 cites W2082344206 @default.
• W2071569295 cites W2089281926 @default.
• W2071569295 cites W2090493193 @default.
• W2071569295 cites W2098447871 @default.
• W2071569295 cites W2106758749 @default.
• W2071569295 cites W2107411106 @default.
• W2071569295 cites W2110442885 @default.
• W2071569295 cites W2110728146 @default.
• W2071569295 cites W2119030941 @default.
• W2071569295 cites W2125734749 @default.
• W2071569295 cites W2131597845 @default.
• W2071569295 cites W2142101377 @default.
• W2071569295 cites W2160284047 @default.
• W2071569295 cites W2163189156 @default.
• W2071569295 cites W2165382472 @default.
• W2071569295 cites W4252560545 @default.
• W2071569295 cites W96466420 @default.
• W2071569295 doi "https://doi.org/10.1186/1471-2407-13-305" @default.
• W2071569295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3695856" @default.
• W2071569295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23800335" @default.
• W2071569295 hasPublicationYear "2013" @default.
• W2071569295 type Work @default.
• W2071569295 sameAs 2071569295 @default.
• W2071569295 citedByCount "14" @default.
• W2071569295 countsByYear W20715692952013 @default.
• W2071569295 countsByYear W20715692952014 @default.
• W2071569295 countsByYear W20715692952015 @default.
• W2071569295 countsByYear W20715692952016 @default.
• W2071569295 countsByYear W20715692952017 @default.
• W2071569295 countsByYear W20715692952018 @default.
• W2071569295 countsByYear W20715692952019 @default.
• W2071569295 countsByYear W20715692952022 @default.
• W2071569295 countsByYear W20715692952023 @default.
• W2071569295 crossrefType "journal-article" @default.
• W2071569295 hasAuthorship W2071569295A5005836955 @default.
• W2071569295 hasAuthorship W2071569295A5009600521 @default.
• W2071569295 hasAuthorship W2071569295A5073143460 @default.
• W2071569295 hasAuthorship W2071569295A5076185144 @default.
• W2071569295 hasBestOaLocation W20715692951 @default.
• W2071569295 hasConcept C104317684 @default.
• W2071569295 hasConcept C126322002 @default.
• W2071569295 hasConcept C143998085 @default.
• W2071569295 hasConcept C146357865 @default.
• W2071569295 hasConcept C1491633281 @default.
• W2071569295 hasConcept C151730666 @default.
• W2071569295 hasConcept C202751555 @default.
• W2071569295 hasConcept C204232928 @default.
• W2071569295 hasConcept C207001950 @default.
• W2071569295 hasConcept C2780140570 @default.
• W2071569295 hasConcept C502942594 @default.
• W2071569295 hasConcept C54355233 @default.
• W2071569295 hasConcept C62112901 @default.
• W2071569295 hasConcept C63363279 @default.
• W2071569295 hasConcept C71924100 @default.
• W2071569295 hasConcept C81885089 @default.
• W2071569295 hasConcept C86803240 @default.
• W2071569295 hasConceptScore W2071569295C104317684 @default.
• W2071569295 hasConceptScore W2071569295C126322002 @default.
• W2071569295 hasConceptScore W2071569295C143998085 @default.
• W2071569295 hasConceptScore W2071569295C146357865 @default.
• W2071569295 hasConceptScore W2071569295C1491633281 @default.
• W2071569295 hasConceptScore W2071569295C151730666 @default.
• W2071569295 hasConceptScore W2071569295C202751555 @default.
• W2071569295 hasConceptScore W2071569295C204232928 @default.
• W2071569295 hasConceptScore W2071569295C207001950 @default.
• W2071569295 hasConceptScore W2071569295C2780140570 @default.
• W2071569295 hasConceptScore W2071569295C502942594 @default.
• W2071569295 hasConceptScore W2071569295C54355233 @default.
• W2071569295 hasConceptScore W2071569295C62112901 @default.
• W2071569295 hasConceptScore W2071569295C63363279 @default.
• W2071569295 hasConceptScore W2071569295C71924100 @default.
• W2071569295 hasConceptScore W2071569295C81885089 @default.
• W2071569295 hasConceptScore W2071569295C86803240 @default.
• W2071569295 hasIssue "1" @default.
• W2071569295 hasLocation W20715692951 @default.
• W2071569295 hasLocation W20715692952 @default.
• W2071569295 hasLocation W20715692953 @default.
• W2071569295 hasLocation W20715692954 @default.
• W2071569295 hasOpenAccess W2071569295 @default.

• next