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- W2071569772 abstract "The aim of this study was to evaluate the immunogenicity of NS5A protein of human hepatitis C virus (HCV) when delivered as naked DNA (NS5A DNA), or recombinant protein (rNS5A). DBA/2J mice received NS5A DNA, rNS5A, or NS5A DNA/rNS5A in different prime-boost combinations with a peptidoglycan Immunomax((R)). The weakest response was induced after rNS5A prime and NS5A DNA boost; rNS5A alone induced an immune response with a strong Th2-component; and NS5A DNA alone, a relatively weak secretion of IL-2 and IFN-gamma. The most efficient was co-injection of NS5A DNA and rNS5A, which induced a significant increase in CD4(+) and CD8(+) T-cell counts, anti-NS5A antibodies, specific T-cell proliferation, and proinflammatory cytokine production in vitro against a broad spectrum of NS5A epitopes. Administration of the mixture of adjuvanted DNA and protein immunogens can be selected as the best regimen for further preclinical HCV-vaccine trials." @default.
- W2071569772 created "2016-06-24" @default.
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- W2071569772 date "2010-02-01" @default.
- W2071569772 modified "2023-10-01" @default.
- W2071569772 title "The successful immune response against hepatitis C nonstructural protein 5A (NS5A) requires heterologous DNA/protein immunization" @default.
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- W2071569772 doi "https://doi.org/10.1016/j.vaccine.2009.10.097" @default.
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