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• W2071573411 abstract "NMDA and kisspeptins can stimulate gonadotropin-releasing hormone (GnRH) release after peripheral or central administration in mice. To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in <i>Kiss1</i>- or <i>Gpr54</i> (<i>Kiss1r</i>)-null mutant mice. Peripheral injection of NMDA failed to stimulate GnRH/LH release in prepubertal or gonadally intact mutant male mice. Dual-labeling experiments indicated a direct activation of <i>Kiss1</i>-expressing neurons in the arcuate nucleus. In contrast, central injection of NMDA into the lateral ventricle increased plasma LH levels in both <i>Kiss1</i> and <i>Gpr54</i> mutant male mice similar to the responses in wild-type mice. Central injection of NMDA stimulated c-Fos expression throughout the hypothalamus but not in GnRH neurons, suggesting an action at the nerve terminals only. In contrast, kisspeptin-10 stimulated LH release after both central and peripheral injection but induced c-Fos expression in GnRH neurons only after central administration. Finally, central injection of NMDA induces c-Fos expression in catecholamine- and nitric oxide-producing neurons in the hypothalamus of mutant mice, indicating a possible kisspeptin-independent GnRH/LH release by NMDA through activation of these neurons. Thus, NMDA may act at both GnRH cell bodies (kisspeptin-independent) and nerve terminals (kisspeptin-dependent) in a dual way to participate in the GnRH/LH secretion in the male mouse." @default.
• W2071573411 created "2016-06-24" @default.
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• W2071573411 date "2010-06-23" @default.
• W2071573411 modified "2023-10-18" @default.
• W2071573411 title "Kisspeptin Signaling Is Required for Peripheral But Not Central Stimulation of Gonadotropin-Releasing Hormone Neurons by NMDA" @default.
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• W2071573411 doi "https://doi.org/10.1523/jneurosci.5486-09.2010" @default.
• W2071573411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6634616" @default.
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