FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071581388> ?p ?o ?g. }

• W2071581388 endingPage "2083" @default.
• W2071581388 startingPage "2076" @default.
• W2071581388 abstract "Liposarcomas are a representative group of soft tissue sarcomas with variably hampered adipogenesis, which is most exemplified by its dedifferentiated subtype. However, the factor(s) responsible for inhibiting adipocyte differentiation remains unknown. A recent gene expression profiling study identified several unique genes that were highly expressed in dedifferentiated liposarcoma, and the gene encoding calreticulin (CALR), a major Ca(2+)-buffering protein that can inhibit adipocyte differentiation, was found to be overexpressed. Thus, we investigated the expression of calreticulin in 45 cases of liposarcomas, including 15 dedifferentiated tumors, at both the protein and mRNA levels. Immunohistochemically, calreticulin was consistently expressed in the dedifferentiated areas of dedifferentiated liposarcomas and commonly observed in atypical stromal cells and/or lipoblasts in the well-differentiated areas (87%), whereas large vacuolated adipocytic cells in either the tumors or normal fat were essentially negative. These results were further supported by the findings of Western blot and quantitative RT-PCR analyses. Although abnormalities in 19p13.1-13.2 where CALR is localized were uncommon in the dedifferentiated liposarcomas examined by fluorescence in situ hybridization, expression of miR-1257, a putative microRNA that targets calreticulin, was suppressed in the dedifferentiated subtype. The down-regulation of calreticulin by small-interfering RNA could induce adipogenesis in dedifferentiated liposarcoma cells and reduce cell proliferation. Our results therefore suggest that aberrantly expressed calreticulin in dedifferentiated liposarcoma is involved in its dedifferenitation and/or tumor progression." @default.
• W2071581388 created "2016-06-24" @default.
• W2071581388 creator A5032721156 @default.
• W2071581388 creator A5039403070 @default.
• W2071581388 creator A5070733768 @default.
• W2071581388 date "2012-05-01" @default.
• W2071581388 modified "2023-09-24" @default.
• W2071581388 title "Aberrant Calreticulin Expression Is Involved in the Dedifferentiation of Dedifferentiated Liposarcoma" @default.
• W2071581388 cites W1907219612 @default.
• W2071581388 cites W1964963490 @default.
• W2071581388 cites W1972990982 @default.
• W2071581388 cites W1980858272 @default.
• W2071581388 cites W1980980780 @default.
• W2071581388 cites W1983949292 @default.
• W2071581388 cites W2002995168 @default.
• W2071581388 cites W2019011732 @default.
• W2071581388 cites W2020585594 @default.
• W2071581388 cites W2027059052 @default.
• W2071581388 cites W2038491907 @default.
• W2071581388 cites W2046314426 @default.
• W2071581388 cites W2058373115 @default.
• W2071581388 cites W2069170284 @default.
• W2071581388 cites W2077109046 @default.
• W2071581388 cites W2085442947 @default.
• W2071581388 cites W2095626453 @default.
• W2071581388 cites W2100878513 @default.
• W2071581388 cites W2113799786 @default.
• W2071581388 cites W2117649489 @default.
• W2071581388 cites W2134410951 @default.
• W2071581388 cites W2145965997 @default.
• W2071581388 cites W2153928704 @default.
• W2071581388 cites W2163431847 @default.
• W2071581388 cites W4239012520 @default.
• W2071581388 cites W4245305755 @default.
• W2071581388 doi "https://doi.org/10.1016/j.ajpath.2012.01.042" @default.
• W2071581388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22429966" @default.
• W2071581388 hasPublicationYear "2012" @default.
• W2071581388 type Work @default.
• W2071581388 sameAs 2071581388 @default.
• W2071581388 citedByCount "25" @default.
• W2071581388 countsByYear W20715813882013 @default.
• W2071581388 countsByYear W20715813882014 @default.
• W2071581388 countsByYear W20715813882015 @default.
• W2071581388 countsByYear W20715813882016 @default.
• W2071581388 countsByYear W20715813882017 @default.
• W2071581388 countsByYear W20715813882018 @default.
• W2071581388 countsByYear W20715813882019 @default.
• W2071581388 countsByYear W20715813882022 @default.
• W2071581388 crossrefType "journal-article" @default.
• W2071581388 hasAuthorship W2071581388A5032721156 @default.
• W2071581388 hasAuthorship W2071581388A5039403070 @default.
• W2071581388 hasAuthorship W2071581388A5070733768 @default.
• W2071581388 hasConcept C104317684 @default.
• W2071581388 hasConcept C122927707 @default.
• W2071581388 hasConcept C142724271 @default.
• W2071581388 hasConcept C145059251 @default.
• W2071581388 hasConcept C150194340 @default.
• W2071581388 hasConcept C153911025 @default.
• W2071581388 hasConcept C158617107 @default.
• W2071581388 hasConcept C170493617 @default.
• W2071581388 hasConcept C180361614 @default.
• W2071581388 hasConcept C18431079 @default.
• W2071581388 hasConcept C198826908 @default.
• W2071581388 hasConcept C2775960820 @default.
• W2071581388 hasConcept C2778256501 @default.
• W2071581388 hasConcept C2779568860 @default.
• W2071581388 hasConcept C2780545995 @default.
• W2071581388 hasConcept C47450691 @default.
• W2071581388 hasConcept C502942594 @default.
• W2071581388 hasConcept C54355233 @default.
• W2071581388 hasConcept C71924100 @default.
• W2071581388 hasConcept C81439078 @default.
• W2071581388 hasConcept C86803240 @default.
• W2071581388 hasConcept C95444343 @default.
• W2071581388 hasConceptScore W2071581388C104317684 @default.
• W2071581388 hasConceptScore W2071581388C122927707 @default.
• W2071581388 hasConceptScore W2071581388C142724271 @default.
• W2071581388 hasConceptScore W2071581388C145059251 @default.
• W2071581388 hasConceptScore W2071581388C150194340 @default.
• W2071581388 hasConceptScore W2071581388C153911025 @default.
• W2071581388 hasConceptScore W2071581388C158617107 @default.
• W2071581388 hasConceptScore W2071581388C170493617 @default.
• W2071581388 hasConceptScore W2071581388C180361614 @default.
• W2071581388 hasConceptScore W2071581388C18431079 @default.
• W2071581388 hasConceptScore W2071581388C198826908 @default.
• W2071581388 hasConceptScore W2071581388C2775960820 @default.
• W2071581388 hasConceptScore W2071581388C2778256501 @default.
• W2071581388 hasConceptScore W2071581388C2779568860 @default.
• W2071581388 hasConceptScore W2071581388C2780545995 @default.
• W2071581388 hasConceptScore W2071581388C47450691 @default.
• W2071581388 hasConceptScore W2071581388C502942594 @default.
• W2071581388 hasConceptScore W2071581388C54355233 @default.
• W2071581388 hasConceptScore W2071581388C71924100 @default.
• W2071581388 hasConceptScore W2071581388C81439078 @default.
• W2071581388 hasConceptScore W2071581388C86803240 @default.
• W2071581388 hasConceptScore W2071581388C95444343 @default.
• W2071581388 hasFunder F4320334764 @default.
• W2071581388 hasIssue "5" @default.

• next