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- W2071582093 abstract "Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H(2)O(2)-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H(2)O(2) (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease." @default.
- W2071582093 created "2016-06-24" @default.
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- W2071582093 date "2006-04-25" @default.
- W2071582093 modified "2023-10-14" @default.
- W2071582093 title "HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway" @default.
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- W2071582093 doi "https://doi.org/10.1016/j.febslet.2006.04.041" @default.
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