Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071585087> ?p ?o ?g. }
- W2071585087 endingPage "1246" @default.
- W2071585087 startingPage "1237" @default.
- W2071585087 abstract "Superoxide (O2⋅-) is the proximal mitochondrial reactive oxygen species underlying pathology and redox signaling. This central role prioritizes development of a mitochondria-targeted reagent selective for controlling O2⋅-. We have conjugated a mitochondria-targeting triphenylphosphonium (TPP) cation to a O2⋅--selective pentaaza macrocyclic Mn(II) superoxide dismutase (SOD) mimetic to make MitoSOD, a mitochondria-targeted SOD mimetic. MitoSOD showed rapid and extensive membrane potential-dependent uptake into mitochondria without loss of Mn and retained SOD activity. Pulse radiolysis measurements confirmed that MitoSOD was a very effective catalytic SOD mimetic. MitoSOD also catalyzes the ascorbate-dependent reduction of O2⋅-. The combination of mitochondrial uptake and O2⋅- scavenging by MitoSOD decreased inactivation of the matrix enzyme aconitase caused by O2⋅-. MitoSOD is an effective mitochondria-targeted macrocyclic SOD mimetic that selectively protects mitochondria from O2⋅- damage." @default.
- W2071585087 created "2016-06-24" @default.
- W2071585087 creator A5004907971 @default.
- W2071585087 creator A5011574979 @default.
- W2071585087 creator A5017959770 @default.
- W2071585087 creator A5021812477 @default.
- W2071585087 creator A5022839790 @default.
- W2071585087 creator A5042262530 @default.
- W2071585087 creator A5043961236 @default.
- W2071585087 creator A5055705983 @default.
- W2071585087 creator A5060532049 @default.
- W2071585087 creator A5062511010 @default.
- W2071585087 creator A5064568611 @default.
- W2071585087 creator A5069939121 @default.
- W2071585087 creator A5079557293 @default.
- W2071585087 creator A5087637841 @default.
- W2071585087 date "2012-10-01" @default.
- W2071585087 modified "2023-10-18" @default.
- W2071585087 title "A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic" @default.
- W2071585087 cites W106697270 @default.
- W2071585087 cites W1206624 @default.
- W2071585087 cites W1507385544 @default.
- W2071585087 cites W1512824421 @default.
- W2071585087 cites W1523213544 @default.
- W2071585087 cites W1533259206 @default.
- W2071585087 cites W1592353488 @default.
- W2071585087 cites W1623473717 @default.
- W2071585087 cites W1636269875 @default.
- W2071585087 cites W1973318867 @default.
- W2071585087 cites W1975045295 @default.
- W2071585087 cites W1987096917 @default.
- W2071585087 cites W1989548466 @default.
- W2071585087 cites W1993420568 @default.
- W2071585087 cites W2000874404 @default.
- W2071585087 cites W2002625920 @default.
- W2071585087 cites W2010205913 @default.
- W2071585087 cites W2010300252 @default.
- W2071585087 cites W2012309329 @default.
- W2071585087 cites W2013805538 @default.
- W2071585087 cites W2017692041 @default.
- W2071585087 cites W2020585998 @default.
- W2071585087 cites W2027498284 @default.
- W2071585087 cites W2028773523 @default.
- W2071585087 cites W2031172417 @default.
- W2071585087 cites W2031226208 @default.
- W2071585087 cites W2031787647 @default.
- W2071585087 cites W2042393861 @default.
- W2071585087 cites W2042793067 @default.
- W2071585087 cites W2045349837 @default.
- W2071585087 cites W2046396329 @default.
- W2071585087 cites W2051802937 @default.
- W2071585087 cites W2058130842 @default.
- W2071585087 cites W2064176864 @default.
- W2071585087 cites W2072854658 @default.
- W2071585087 cites W2073361557 @default.
- W2071585087 cites W2080233198 @default.
- W2071585087 cites W2080432368 @default.
- W2071585087 cites W2083883672 @default.
- W2071585087 cites W2090913071 @default.
- W2071585087 cites W2093562926 @default.
- W2071585087 cites W2100151397 @default.
- W2071585087 cites W2100951378 @default.
- W2071585087 cites W2115054403 @default.
- W2071585087 cites W2122341467 @default.
- W2071585087 cites W2124872976 @default.
- W2071585087 cites W2126078273 @default.
- W2071585087 cites W2140014506 @default.
- W2071585087 cites W2144674004 @default.
- W2071585087 cites W2144816500 @default.
- W2071585087 cites W2147193143 @default.
- W2071585087 cites W2148066840 @default.
- W2071585087 cites W2153598184 @default.
- W2071585087 cites W2162583612 @default.
- W2071585087 cites W34139385 @default.
- W2071585087 doi "https://doi.org/10.1016/j.chembiol.2012.08.005" @default.
- W2071585087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23102218" @default.
- W2071585087 hasPublicationYear "2012" @default.
- W2071585087 type Work @default.
- W2071585087 sameAs 2071585087 @default.
- W2071585087 citedByCount "50" @default.
- W2071585087 countsByYear W20715850872012 @default.
- W2071585087 countsByYear W20715850872013 @default.
- W2071585087 countsByYear W20715850872014 @default.
- W2071585087 countsByYear W20715850872015 @default.
- W2071585087 countsByYear W20715850872016 @default.
- W2071585087 countsByYear W20715850872017 @default.
- W2071585087 countsByYear W20715850872018 @default.
- W2071585087 countsByYear W20715850872020 @default.
- W2071585087 countsByYear W20715850872021 @default.
- W2071585087 countsByYear W20715850872022 @default.
- W2071585087 countsByYear W20715850872023 @default.
- W2071585087 crossrefType "journal-article" @default.
- W2071585087 hasAuthorship W2071585087A5004907971 @default.
- W2071585087 hasAuthorship W2071585087A5011574979 @default.
- W2071585087 hasAuthorship W2071585087A5017959770 @default.
- W2071585087 hasAuthorship W2071585087A5021812477 @default.
- W2071585087 hasAuthorship W2071585087A5022839790 @default.
- W2071585087 hasAuthorship W2071585087A5042262530 @default.