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- W2071593607 endingPage "183" @default.
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- W2071593607 abstract "A growing body of data has revealed that specific nutrient deficiencies contribute to microvascular and cellular dysfunction following critical illness. Further, targeted administration of these 'pharmaconutrients' may reverse or improve this dysfunction and improve clinical outcome.Specific nutrient therapy with glutamine protects cellular metabolism and vascular function via induction of heat shock proteins, which are key proteins found to be deficient following acute illness. Arginine becomes rapidly deficient following trauma and surgery. This leads to significant immunosuppression, which when treated by arginine administration significantly reduces postoperative infection. Omega-3 fatty acids attenuate the inflammatory response and provide for resolution of ongoing inflammatory injury via production of resolvins/protectins. Antioxidants (vitamin C and selenium) and trace elements (zinc) become rapidly depleted in critical illness and replacement appears vital to ensure optimal cellular and microvascular function. Data on targeted metabolic (mitochondrial) therapies (i.e. co-enzyme Q10) show promise to improve myocardial function following cardiac surgery.These specific nutrients have newly discovered vital mechanistic roles in the optimization of cellular and microcirculatory function in critical illness and injury. A growing body of literature is demonstrating that correction of key nutrient deficiencies via therapeutic administration of these pharmaconutrients can improve clinical outcome in critically ill patients." @default.
- W2071593607 created "2016-06-24" @default.
- W2071593607 creator A5002855071 @default.
- W2071593607 creator A5008050145 @default.
- W2071593607 creator A5013408449 @default.
- W2071593607 creator A5059865302 @default.
- W2071593607 date "2009-04-01" @default.
- W2071593607 modified "2023-09-27" @default.
- W2071593607 title "Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness" @default.
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- W2071593607 doi "https://doi.org/10.1097/aco.0b013e328328d32f" @default.