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• W2071601326 abstract "Objective: To evaluate roles of the Akt signaling pathway in oncogenesis and cytodifferentiation of odontogenic tumors, expression of phosphorylated Akt (pAkt), PI3K, and PTEN was analyzed in ameloblastic tumors as well as in tooth germs. Methods: 11 tooth germs, 40 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with antibodies against pAkt, PI3K, and PTEN. Results: Immunoreactivity for pAkt, PI3K, and PTEN was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and ameloblastic tumors. The levels of immunoreactivity for pAkt and PI3K were slightly higher in ameloblastic tumors than in tooth germs. Plexiform ameloblastomas showed significantly higher expression of PI3K than follicular ameloblastomas, and PI3K immunoreactivity in ameloblastomas without cellular variation was significantly higher than that in acanthomatous ameloblastomas. The level of PTEN immunoreactivity was significantly lower in ameloblastomas than in tooth germs. Conclusion: Expression of pAkt, PI3K, and PTEN in tooth germs and ameloblastic tumors suggests that these signaling molecules regulate cell survival and growth in normal and neoplastic odontogenic tissues by mediating growth factor signals. Increased expression of pAkt and PI3K and decreased expression of PTEN in ameloblastic tumors may participate in oncogenesis of odontogenic epithelium by activating the Akt signaling pathway." @default.
• W2071601326 created "2016-06-24" @default.
• W2071601326 creator A5024399853 @default.
• W2071601326 creator A5087167224 @default.
• W2071601326 date "2007-09-01" @default.
• W2071601326 modified "2023-09-29" @default.
• W2071601326 title "Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors" @default.
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• W2071601326 doi "https://doi.org/10.1111/j.1601-0825.2006.01321.x" @default.
• W2071601326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17714348" @default.
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