FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071609761> ?p ?o ?g. }

• W2071609761 endingPage "683" @default.
• W2071609761 startingPage "673" @default.
• W2071609761 abstract "Although large increases in neuronal intracellular calcium concentrations ([Ca2+]i) are lethal, moderate increases in [Ca2+]i of 50–200 nM may induce immediate or long-term tolerance of ischemia or other stresses. In neurons in rat hippocampal slice cultures, we determined the relationship between [Ca2+]i, cell death, and Ca2+-dependent neuroprotective signals before and after a 45 min period of oxygen and glucose deprivation (OGD). Thirty minutes before OGD, [Ca2+]i was increased in CA1 neurons by 40–200 nM with 1 nM–1 μM of a Ca2+-selective ionophore (calcimycin or ionomycin-“Ca2+ preconditioning”). Ca2+ preconditioning greatly reduced cell death in CA1, CA3 and dentate during the following 7 days, even though [Ca2+]i was similar (approximately 2 μM) in preconditioned and control neurons 1 h after the OGD. When pre-OGD [Ca2+]i was lowered to 25 nM (10 nM ionophore in Ca2+-free medium) or increased to 8 μM (10 μM ionophore), more than 90% of neurons died. Increased levels of the anti-apoptotic protein protein kinase B (Akt) and the MAP kinase ERK (p42/44) were present in preconditioned slices after OGD. Reducing Ca2+ influx, inhibiting calmodulin, and preventing Akt or MAP kinase p42/44 upregulation prevented Ca2+ preconditioning, supporting a specific role for Ca2+ in the neuroprotective process. Further, in continuously oxygenated cultured hippocampal/cortical neurons, preconditioning for 30 min with 10 nM ionomycin reduced cell death following a 4 μM increase in [Ca2+]i elicited by 1 μM ionomycin. Thus, a zone of moderately increased [Ca2+]i before a potentially lethal insult promotes cell survival, uncoupling subsequent large increases in [Ca2+]i from initiating cell death processes." @default.
• W2071609761 created "2016-06-24" @default.
• W2071609761 creator A5028649792 @default.
• W2071609761 creator A5049817954 @default.
• W2071609761 date "2004-01-01" @default.
• W2071609761 modified "2023-09-29" @default.
• W2071609761 title "Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neurons" @default.
• W2071609761 cites W1585639756 @default.
• W2071609761 cites W1599277155 @default.
• W2071609761 cites W1605897432 @default.
• W2071609761 cites W1824170643 @default.
• W2071609761 cites W1960924050 @default.
• W2071609761 cites W1970031478 @default.
• W2071609761 cites W1975823509 @default.
• W2071609761 cites W1977497197 @default.
• W2071609761 cites W1977653137 @default.
• W2071609761 cites W2002933697 @default.
• W2071609761 cites W2011270545 @default.
• W2071609761 cites W2015807826 @default.
• W2071609761 cites W2035090622 @default.
• W2071609761 cites W2059996601 @default.
• W2071609761 cites W2066581734 @default.
• W2071609761 cites W2069894419 @default.
• W2071609761 cites W2071452513 @default.
• W2071609761 cites W2072926617 @default.
• W2071609761 cites W2076428367 @default.
• W2071609761 cites W2079054696 @default.
• W2071609761 cites W2083229096 @default.
• W2071609761 cites W2084143396 @default.
• W2071609761 cites W2085711301 @default.
• W2071609761 cites W2103131046 @default.
• W2071609761 cites W2111580310 @default.
• W2071609761 cites W2111945921 @default.
• W2071609761 cites W2144918294 @default.
• W2071609761 cites W2154035441 @default.
• W2071609761 cites W2171372231 @default.
• W2071609761 cites W4234842415 @default.
• W2071609761 cites W4253274087 @default.
• W2071609761 cites W4301760834 @default.
• W2071609761 doi "https://doi.org/10.1016/j.neuroscience.2004.05.035" @default.
• W2071609761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15283966" @default.
• W2071609761 hasPublicationYear "2004" @default.
• W2071609761 type Work @default.
• W2071609761 sameAs 2071609761 @default.
• W2071609761 citedByCount "71" @default.
• W2071609761 countsByYear W20716097612012 @default.
• W2071609761 countsByYear W20716097612013 @default.
• W2071609761 countsByYear W20716097612014 @default.
• W2071609761 countsByYear W20716097612015 @default.
• W2071609761 countsByYear W20716097612016 @default.
• W2071609761 countsByYear W20716097612017 @default.
• W2071609761 countsByYear W20716097612018 @default.
• W2071609761 countsByYear W20716097612019 @default.
• W2071609761 countsByYear W20716097612020 @default.
• W2071609761 countsByYear W20716097612021 @default.
• W2071609761 countsByYear W20716097612022 @default.
• W2071609761 crossrefType "journal-article" @default.
• W2071609761 hasAuthorship W2071609761A5028649792 @default.
• W2071609761 hasAuthorship W2071609761A5049817954 @default.
• W2071609761 hasConcept C12554922 @default.
• W2071609761 hasConcept C148762608 @default.
• W2071609761 hasConcept C169760540 @default.
• W2071609761 hasConcept C178790620 @default.
• W2071609761 hasConcept C181080969 @default.
• W2071609761 hasConcept C185592680 @default.
• W2071609761 hasConcept C25498285 @default.
• W2071609761 hasConcept C2776989580 @default.
• W2071609761 hasConcept C2779014961 @default.
• W2071609761 hasConcept C519063684 @default.
• W2071609761 hasConcept C55493867 @default.
• W2071609761 hasConcept C79879829 @default.
• W2071609761 hasConcept C86803240 @default.
• W2071609761 hasConcept C95444343 @default.
• W2071609761 hasConcept C98274493 @default.
• W2071609761 hasConceptScore W2071609761C12554922 @default.
• W2071609761 hasConceptScore W2071609761C148762608 @default.
• W2071609761 hasConceptScore W2071609761C169760540 @default.
• W2071609761 hasConceptScore W2071609761C178790620 @default.
• W2071609761 hasConceptScore W2071609761C181080969 @default.
• W2071609761 hasConceptScore W2071609761C185592680 @default.
• W2071609761 hasConceptScore W2071609761C25498285 @default.
• W2071609761 hasConceptScore W2071609761C2776989580 @default.
• W2071609761 hasConceptScore W2071609761C2779014961 @default.
• W2071609761 hasConceptScore W2071609761C519063684 @default.
• W2071609761 hasConceptScore W2071609761C55493867 @default.
• W2071609761 hasConceptScore W2071609761C79879829 @default.
• W2071609761 hasConceptScore W2071609761C86803240 @default.
• W2071609761 hasConceptScore W2071609761C95444343 @default.
• W2071609761 hasConceptScore W2071609761C98274493 @default.
• W2071609761 hasIssue "3" @default.
• W2071609761 hasLocation W20716097611 @default.
• W2071609761 hasLocation W20716097612 @default.
• W2071609761 hasOpenAccess W2071609761 @default.
• W2071609761 hasPrimaryLocation W20716097611 @default.
• W2071609761 hasRelatedWork W1765098545 @default.
• W2071609761 hasRelatedWork W1972560251 @default.
• W2071609761 hasRelatedWork W1987947024 @default.
• W2071609761 hasRelatedWork W1990058038 @default.

• next