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- W2071613029 abstract "In the study of long-term potentiation (LTP) in the dentate gyrus, the magnitude of the initial slope of the evoked synaptic potential (ESP) in the region of the granule cell layer, is commonly used as a measure of synaptic efficacy at the site of the perforant path (PP) input. To investigate the viability of this assumption, in rats anesthetized with either chloropent or urethane, LTP was induced by tetanic stimulation of the PP and ESPs were measured simultaneously at both the soma and dendritic site of the PP input. Following LTP, the two responses were decoupled, the somal response being greater than the dendritic in rats anesthetized with chloropent, the opposite being true in urethanized animals. We conclude that in investigating changes in synaptic efficacy following LTP, measurements should be taken at the site of the PP input." @default.
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- W2071613029 date "1988-10-01" @default.
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- W2071613029 title "Comparative extracellular current flow at dendrites and soma of dentate granule cells during long-term potentiation" @default.
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- W2071613029 doi "https://doi.org/10.1016/0304-3940(88)90056-0" @default.
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