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• W2071613856 endingPage "36" @default.
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• W2071613856 abstract "During the growth phase of oogenesis, oocytes acquire the ability to undergo meiotic maturation. Although the molecular basis of this meiotic competence is unknown, specific differences in microtubular organization exist between incompetent and competent mammalian oocytes. Mitogen-activated protein (MAP) kinase has been implicated in microtubular regulation and is present in fully grown competent oocytes of mice, suggesting a possible role for this protein in the acquisition of meiotic competence. We report that the MAP kinase species, p42ERK2 and p44ERK1, were detectable by immunoblotting in incompetent oocytes at the early stages of oocyte growth and throughout subsequent growth and acquisition of competence. In partially competent oocytes, which can enter metaphase but cannot complete the first meiotic division, both p42ERK2 and p44ERK1 became phosphorylated, as judged by retarded electrophoretic mobility, and a morphologically normal spindle was assembled. In incompetent oocytes, which cannot enter metaphase, p42ERK2 and p44ERK1 remained nonphosphorylated. When these oocytes were treated with okadaic acid, an inhibitor of protein phosphatases 1 and 2A, a portion of them entered metaphase and the slow-migrating phosphorylated forms of p42ERK2 and p44ERK1 were observed. These phosphorylated forms appeared more rapidly, relative to the time of entry into metaphase, than during maturation of fully competent oocytes. The remaining incompetent oocytes, which did not enter metaphase during okadaic acid treatment, also did not generate slow-migrating p42ERK2 and p44ERK1. These results suggest that the acquisition of meiotic competence during oocyte growth is not linked to the de novo appearance of p42ERK2 or p44ERK1, that the failure of partially competent oocytes to complete meiosis I reflects a defect acting downstream or independently of MAP kinase phosphorylation, and that the ability of meiotically incompetent oocytes to generate phosphorylated forms of p42ERK2 and p44ERK1 in response to okadaic acid is linked to the ability to enter metaphase. © 1995 Wiley-Liss, Inc." @default.
• W2071613856 created "2016-06-24" @default.
• W2071613856 creator A5025711910 @default.
• W2071613856 creator A5045813539 @default.
• W2071613856 date "1995-05-01" @default.
• W2071613856 modified "2023-10-16" @default.
• W2071613856 title "Mitogen-activated protein (MAP) kinase during the acquisition of meiotic competence by growing oocytes of the mouse" @default.
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• W2071613856 doi "https://doi.org/10.1002/mrd.1080410106" @default.
• W2071613856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7619503" @default.
• W2071613856 hasPublicationYear "1995" @default.
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