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• W2071617037 abstract "Cutaneous T-cell lymphoma is a malignancy of T cells that express a clone-specific heterodimer T-cell receptor for antigen. The second recognized case of an epidermotropic malignancy of T-cells expressing gamma/delta T-cell receptor-expressing cells is reported. The immunophenotype of the malignant T-cells was CD3+, CD2+, CD7+, gamma/delta T-cell receptor+, CD4−, CD8−, and alpha/beta T-cell receptor−. The clinical features were remarkable for extreme epidermotropism with a scant dermal lymphomatous infiltrate. Profound keratinocyte necrosis occurred in areas of malignant skin infiltrates. Despite cutaneous lesions covering more than 50% of the skin surface of the patient, no adenopathy or splenomegaly was detected. The intense epidermotropism of this patient's gamma/delta T-cell receptor-expressing cells and the putative cytolytic properties of CD4− CD8− gamma/delta contributed to the destruction of epidermis. Remission was induced with a combination of electron beam and extracorporeal photochemotherapy." @default.
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• W2071617037 date "1992-05-01" @default.
• W2071617037 modified "2023-10-10" @default.
• W2071617037 title "Correlations of unique clinical, immunotypic, and histologic findings in cutaneous gamma/delta T-cell lymphoma" @default.
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• W2071617037 doi "https://doi.org/10.1016/0190-9622(92)70125-y" @default.
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